p53 plays a crucial role in safely reprogramming human somatic cells to pluripotency while balancing genome stability. This balancing act is key for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA 🧪

New data reveals that after bivalent CAR T cell therapy for recurrent GBM, prolonged survival was linked to the endogenous immune response; detailed profiling of CSF was key! PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in Duchenne muscular dystrophy using LEAPER 2.0! Circular arRNAs enable long-term exon skipping, reversing muscle degeneration in monkeys and humans. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cellular senescence shows diverse states across tissues in aging and disease, revealing 40+ senotypes and enabling targeted therapies via AI-driven multi-omics insights. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AD brain analysis of 311 samples revealed >1,000× sSNVs in cancer driver genes, linked to clonal hematopoiesis, driving expansion in microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting advancements in RNA editing with LEAPER 3.0! Engineered ADAR-recruiting RNAs enhance precision and efficiency by using AlphaFold 3 structure insights. Future of gene therapy? PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA 🧪

New research reveals that human breast cancer macrometastases exploit a unique 3D morphogenetic process, activating a metastatic trabecular morphogenesis (MTM) gene program for expansion! 📈🔬 #CancerResearch PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #RNA 🧪

AI-driven discovery of GPNMB CAR T cells reveals a novel multi-cancer therapy, refining targets with single-cell RNA seq from 1k+ human samples. Exciting progress! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CD8+ T cells utilize cysteine for both glutathione production, enhancing effector function, and sulfur for NFS1-dependent FeS cluster synthesis, crucial for proliferation. NFS1 deletion leads to T cell… PMID:41923640, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00279-5 #RNA 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying key regulators influencing cell fate shifts. A game changer in cell-state prediction! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain enhance sustained attention, challenging the role of cholinergic neurons! PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin causes neuronal death by activating nucleotide excision repair (NER), which paradoxically promotes damage instead of protecting neurons. #Neurotoxicity PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🔗 Leveraging Foundation Models for the Characterization of Small-RNA Properties. doi.org/10.34133/csb...

📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

@kingscollegelondon.bsky.social @aiatkings.bsky.social @csbj.org #Genomics #ComputationalBiology #Bioinformatics #RNA #AI

New findings show that allergens trigger PAR1-dependent ferritinophagy, raising intracellular iron levels, crucial for noncanonical GSDMD activation in allergic airway diseases. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A study on NSCs reveals that MAP1B, a microtubule-associated protein, shuttles to the nucleus, linking cytoskeletal dynamics to transcriptional regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered GMPs enable long-term expansion of mouse and human progenitors for tumor immunotherapy, powered by myeloperoxidase's role in proliferation. Transformative! PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel pooled imaging method, VIS-seq, analyzed ~3,000 LMNA & PTEN variants, uncovering high-dimensional phenotypic profiles linked to protein behavior and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism via its virulence factor to thrive in the inflamed gut, fueling oxidative growth in the large intestine and linking to colitis & CRC. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🧬 RNA m5C in cancer: ready for the clinic?
🔬 A new review in LabMed Discovery examines the measurement gap.
🎯 Key insights: assay limitations, reliable quantification & a roadmap to clinical validation.
🔗 doi.org/10.1016/j.lm...
#RNA #CancerBiomarkers

Cells can detect and navigate electrical fields via the receptor TMEM154/Galvanin, guiding movement toward the cathode. A breakthrough in cell migration studies! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪