Researchers from Emory University Department of Medicine propose oleoylethanolamide may be the endogenous ligand for the orphan GPCR GPR3. It stimulates cAMP formation over hours and promotes recruitment of GPR3 to the cell surface thereby increasing signaling: https://ow.ly/sf7v50ZQ7hC #pharmsky 🧪

New research unveils a "disease-associated motor neuron" state in ALS, revealing 1000s of molecular shifts in SOD1-G93A model. Key insights on transcription factors emerge! PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer >5 years before diagnosis, enhancing prevention strategies beyond CANTOS NNT challenges. Notable for early detection impact! PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Check out the ASPET blog on Pharmaco Corner, and read how Dr. Tri Widyawati's experiences at three different World Congresses of Pharmacology shaped her understanding of community and collaboration.

Read the blog at https://ow.ly/l5k550ZJB7K.

IUPHAR/BPS Guide to Pharmacology #pharmsky 🧪

Check out the ASPET blog on Pharmaco Corner, and read how Dr. Tri Widyawati's experiences at three different World Congresses of Pharmacology shaped her understanding of community and collaboration.

Read the blog at https://ow.ly/l5k550ZJB7K.

IUPHAR/BPS Guide to Pharmacology #pharmsky 🧪

Study reveals that targeting macrophage ferritin heavy chain (FTH1) can reduce ferroptosis and lung damage in ARDS. Elevated serum ex-ferritin ties to worse outcomes. PMID:42364999, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74828-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed VIS-seq, an image-based method revealing complex effects of ~3,000 LMNA & PTEN variants. Identified diverse phenotypic changes, including protein localization & cell architecture. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky 🧪

Polyploidy is a key force in angiosperm evolution, with 132 ancient whole-genome duplication events identified across 470 species, revealing non-random clustering—fascinating! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG 🧪

BsAb EVs target FAP⁺ fibroblasts in 1 surgical model, redirecting T cells to reduce epidural fibrosis effectively post-surgery. Potential game-changer for recovery! PMID:42364978, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74883-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

T cell activation triggers ADAM17-mediated cleavage via a 15-aa motif, enabling control over CAR expression. This innovation reduces CAR levels based on tonic signaling. PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies E3 ubiquitin ligase MARCH7 as a crucial ferro-guardian against ferroptosis, regulating iron homeostasis by targeting NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway senses dsDNA, linking innate immunity and cellular responses. Key to antitumor immunity, it also drives inflammatory disorders. #Immunology #Research PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Splenic macrophage-B cell axis in cerebral malaria drives systemic autoimmunity. CD36 autoantibodies, found in 97% of patients, target infected RBCs, causing pathological effects. PMID:42364976, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74882-4 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel library of 84 CRISPR-Cas9 mouse lines enables in vivo screening of host factors in influenza A research, overcoming bottlenecks in functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Recent findings reveal that MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to gene regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Cysteine's sulfur is crucial for CD8⁺ T cell fate, driving 60% toward glutathione and 40% for iron-sulfur clusters, influencing proliferation and anti-tumor immunity. PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleogenomic analysis of 12 cave lion genomes from over 100,000 years reveals distinct evolutionary paths from modern lions, highlighting unique variants and evidence of ancient gene flow. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky 🧪

AI-driven discovery identifies GPNMB CAR T cells as a promising multi-cancer therapy, refining targets through single-cell RNA seq from 100+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Exploring SMVT with cryo-EM: 3 structures unveiled—occluded, outward-open, inward-open—reveal how it transports vital vitamins. Key to tackling its dysfunction! PMID:42364996, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74948-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪