Innovative design of G_i-biased CB1 agonists, LZD503 & LZD505, targets pain relief while minimizing side effects, paving the way for safer non-opioid therapies. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative evolution model replays 100+ monoclonal germinal center reactions, revealing that B cell competition drives affinity increases in antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Allergens trigger PAR1-dependent ferritinophagy in lung epithelial cells, raising labile iron levels essential for protease-independent GSDMD activation, fueling IL-33 secretion. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA #ASHG 🧪

UPRmt in human microglia disrupts neuron-glia communication & promotes cell aging, revealing new insights into brain stress. PMID:42362883, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02320-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights show that vulnerable motor neurons in ALS shift to a unique "disease-associated" state marked by thousands of molecular changes before cell death. 📉🔍 PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how dynamic ACh signaling in the BLA, crucial for salience processing, links to NAc: D1 neurons promote & D2 neurons suppress! PMID:42362886, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02353-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new AI framework identifies GPNMB as a promising CAR T target across melanoma, leukemia, and colorectal cancer, tackling the challenge of safe therapeutic design. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, integrating gene regulatory networks with RNA velocity to reveal 100+ candidate regulators that shape cell fate transitions. Exciting advancements! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila, with diallyl disulfide leading the way! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 enhances RNA editing by using designed ADAR-recruiting RNAs (arRNAs) for precise, efficient editing. Advances in AlphaFold 3 structure unlock new strategies! PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery identifies GPNMB as a promising CAR T cell target for multi-cancer therapy, optimizing tumor composition through single-cell RNA sequencing. #CancerResearch PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Discover how GCN5-related N-acetyltransferases creatively modify mature lasso peptides, introducing iterative acylation to enhance diversity! PMID:41826761, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02149-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

African populations hold 40% of human genetic diversity but are only 2% of genomic studies. Advocate for national genome projects to improve healthcare equity! PMID:42342701, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74952-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress increases metabolic dysfunction risk in mice when exposed to high-fat diets. Skin-derived KLK14 triggers hypothalamic LRRC7+ astrocytes, linking heat and metabolism. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Osteosarcoma develops in juvenile metaphysis. Study shows p21 induction due to DNA damage in 3-5 immature osteoblast stages; 10-stage maturity path identified. PMID:42363015, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74929-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear envelope budding (NEB) permits the export of large RNA transcripts during myoblast differentiation into myotubes, revealing a vital role in cellular processes. PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Gut bacteria metabolite imidazole propionate linked to Alzheimer's! In 1,196 adults, high plasma levels tied to lower cognitive scores & ADRD biomarkers. Fascinating discovery! PMID:42362546, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74744-z #Medsky #Pharmsky #RNA #ASHG 🧪

Complete response to pembrolizumab in dMMR prostate cancer with TMB >250 mutations/Mb and NK-like, CD4+CD8+ T cells! PMID:42361800, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S266637912600306X?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG 🧪

New study reveals that prion-based switches in S. cerevisiae enhance mutagenesis, enabling rapid adaptation in diverse environments. Key to evolution! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative study tests 3KO porcine kidneys with 4 HTG combos. Results show promise: longer survival in primates, advancing xenotransplantation potential! 🌍👥 PMID:42362566, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74933-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪