🗑️ #Yeast nuclear ubiquitin ligase Uls2 has surprising side job: tagging cytosolic proteins for degradation. Orphaned/ oxidatively damaged proteins aggregate in nucleus & become SUMO-dependent substrate ➡️ = compartment-spanning QC pathway
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

Fermenting Golden Ale :-)

www.miklix.com/brewing/yeas...

#Homebrewing #Yeast #YeastMode #GrainToGlass #CraftYourOwnBeer #Fermentation

haiku #1034

fingers in the jelly jar
hope in the yeast
we are the toaster.

#haiku #fingers #yeast #toaster

🫧 Autophagosome membranes don't just grow by lipid transfer. #Yeast cryo-ET shows vesicles clustering around and fusing with the phagophore rim during expansion, a contribution that was previously attributed only to the nucleation stage

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

50 years baking and still make mistakes.

Put in the fridge to bake in the morning but after a few hours it was already overproofed. Okay, not a huge mistake, but still…

#food #cooking #baking #bread #yeast

What if the key to designing better synthetic #yeast #allotetraploids for industry is not only the nuclear genome, but also the #mitochondria? 🧬⚡
Read the story here: bit.ly/4iISFnB
#FunGIALab #SyntheticBiology
@iatacsic.bsky.social @uio.no

⛓️‍💥 In #Yeast a broken helicase can be worse than no helicase. Inactive Hrq1 binds DNA but can't unwind it= 🙅 inter-strand crosslink repair. ➡️ Sheds light on how partial LoF mutations in human RECQL4 may similarly disrupt genome stability.
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

Fermenting French Saison :-)

www.miklix.com/brewing/yeas...

#Homebrewing #Yeast #YeastMode #GrainToGlass #CraftYourOwnBeer

✂️ The spliceosome has to shed Dib1 before it can start cutting RNA. New #Yeast research shows Dib1's C-terminal tail is what keeps it docked near the catalytic core via Prp8 and Prp31, and losing that tail is enough to kill the cell.

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

Spotlight: Bartolutti, Brar et al. @berkeleymcb.bsky.social (rupress.org/jcb/article/...) describe how physiological UPR induction drives #gametogenesis in budding #yeast. David Pincus and Vladimir Denic discuss the work: rupress.org/jcb/article/...

#Genetics #ProteinHomeostasis

The first non-chaotic(?) week of the semester is here when we can actually get work done! We welcome two new PhD students in the Lab, Soulafa from 🇸🇾 and Gergő from 🇭🇺 who will work with #yeast and other fungi! Good luck and welcome:)

🛟 When DNA breaks in #Yeast, Tel1 phosphorylates Rad9, driving its self-assembly to hold broken ends together & steer repair toward homologous recombination. A Tel1 FAT-domain variant reveals this axis by rescuing end-tethering defects

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

Naumovozyma castellii is a telomerase-deficient #yeast strain that can bypass senescence by rapidly activating an alternative lengthening of telomeres (ALT) mechanism.

New work in #G3journal shows that subtelomeric regions play a key role in the effective activation of ALT.

🔗 buff.ly/pTGuRh8

Just Published !

#TDP43 #ALS #neurodegeneration #yeast #endoplasmicreticulum

onlinelibrary.wiley.com/doi/10.1111/...

New paper in Yeast: Luciano Gomes Fietto & team studied the mechanisms of stress response in the #yeast Spathaspora passalidarum and compared it to S. cerevisiae, uncovering sequence and structural divergence of #transcription factors between the two species.

onlinelibrary.wiley.com/doi/10.1002/...

📈 #Yeast Dhh1 (human DDX6) bridges deadenylation and decapping in mRNA decay, but how it's activated was unclear. Edc3 and Not1 tune its ATPase activity through distinct mechanisms, cooperating for a 200-fold boost

🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...

Making fertiliser out of lees, one of the wine industry's largest waste byproducts. www.thedrinksbusiness.com/2026/09/marl... #wine #winemaking #winenews #yeast #waste #pollution #circulareconomy #sustainability #soil #sustainability #nz #newzealand #goodnews #drinks #lees #vino

Wow, Collaborative Yeast Cross clones, a library of 11,392 segregants! #yeast

A library of #yeast strains captures a substantial fraction of genomic variation while also avoiding the confounding effects of population structure.

Learn more about the construction and characterization of this CYClones library in the September issue of #G3journal
🔗 buff.ly/Mgz7LCv

I'm very proud of my students taking part at the Genetics Miniconference in Szeged today, showing their work for the first time! We divided the posters into 10 blocks, each for a student project:) Congratulations Team! #yeast #lablife