Novel therapy: GPNMB CAR-T cells tackle glioblastoma by dual targeting tumor and myeloid cells, overcoming macrophage-driven growth and heterogeneity issues. 🔬💡 PMID:42386964, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10641-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

9p21.3 is vital for CAD risk, significant in EU, EA, SA, ME but absent in African cohorts. Allelic diversity matters! #HeartHealth PMID:42385718, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00233-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Multiple sclerosis: a chronic autoimmune CNS disorder. 500k+ deal with it yearly. Attacks myelin, causes neurodegeneration & disability. PMID:42384871, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMra2501195 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Recurrent patterns of TOP1-mediated genomic damage in 469 neurons reveal increased somatic mutations in ALS, FTD, and AD, highlighting shared neurodegenerative mechanisms. PMID:42385702, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00700-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new co-culture system using human ESCs and extra-embryonic cells successfully mimics primitive streak formation, shedding light on gastrulation and embryonic diversity. PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

BRAF V600E inhibition leads to sustained neuro & dermal improvements in a patient with neurocutaneous melanosis. PMID:42384401, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1629 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that genetic variant rs17437411 affects blood counts and cancer risk by disrupting the lncRNA HOXA1, highlighting its role in hematopoiesis. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in DMD! Long-term reversal achieved using LEAPER 2.0 with circ-arRNAs for exon skipping in monkeys & humans, restoring muscle function & mobility. 💪 PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rituximab vs Ocrelizumab in MS: In a 24-month trial with 3:2 randomization, 23% had no new T2 lesions on MRI. PMID:42384870, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2600993 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that parvalbumin-expressing inhibitory neurons from the basal forebrain are crucial for sustaining attention, countering prior beliefs about cholinergic neurons. PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough: Efficient intracellular assembly of artificial enzymes enables enantioselective Mannich reactions in cells. Revolutionizing biocatalysis with abiological cofactors! 🌟 PMID:42386753, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75059-9 #Medsky #Pharmsky #RNA #ASHG 🧪

Designs quasisymmetric two-component protein cages using computational strategies inspired by icosahedral viral capsids. Complex nanoscale architecture unlocked! PMID:42162421, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10464-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Deep-Phase, a neural network, deciphers changes in biomolecular condensate morphology due to drugs, linking molecular interactions to mesoscale organization. PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals 1,000× sequencing of 311 brain samples shows somatic variants in cancer genes enrich AD microglia, linking clonal hematopoiesis to neuroinflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Intl consensus unveils new on-pitch concussion protocol for football. Immediate, standardized, evidence-based. ⚽️🤝🧠 PMID:42384398, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2298 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel LLM-assist scoring framework identifies GPNMB as a promising target for CAR T therapies in melanoma, leukemia, and colorectal cancer—boosting treatment efficacy! PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Embryonic macrophages, emerging from yolk sac & fetal liver, shape tissue organization & immunity early on, becoming long-lived. PMID:42386903, Nat Rev Immunol 2026, @NatRevImmunol https://doi.org/10.1038/s41577-026-01327-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study bridges single-cell RNA seq with axonal projections in mouse visual cortex. A leap in linking diverse neurons—quantifies the brain at a new level. PMID:42386969, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10424-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal how VPS13A, a bridge-like lipid-transfer protein, collaborates with the scramblase XK via cryo-EM to mediate lipid transfer at organelle contact sites. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study finds vessel fractional flow reserve (vFFR) from 3D coronary angiography rivals pressure-wire FFR in guiding heart interventions. Mitigates need for pressure wire and hyperemia across 37 sites! PMID:41910382, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2601841 #Medsky #Pharmsky 🧪