Study reveals 1,000× sequencing of 311 brain samples shows somatic variants in cancer genes enrich AD microglia, linking clonal hematopoiesis to neuroinflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Intl consensus unveils new on-pitch concussion protocol for football. Immediate, standardized, evidence-based. ⚽️🤝🧠 PMID:42384398, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2298 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel LLM-assist scoring framework identifies GPNMB as a promising target for CAR T therapies in melanoma, leukemia, and colorectal cancer—boosting treatment efficacy! PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Embryonic macrophages, emerging from yolk sac & fetal liver, shape tissue organization & immunity early on, becoming long-lived. PMID:42386903, Nat Rev Immunol 2026, @NatRevImmunol https://doi.org/10.1038/s41577-026-01327-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study bridges single-cell RNA seq with axonal projections in mouse visual cortex. A leap in linking diverse neurons—quantifies the brain at a new level. PMID:42386969, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10424-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal how VPS13A, a bridge-like lipid-transfer protein, collaborates with the scramblase XK via cryo-EM to mediate lipid transfer at organelle contact sites. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear and cytosolic proteomic profiling in human and murine neural stem cells reveals abundant cytoskeletal proteins like MAP1B that regulate fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a conserved ZnF domain protein, to sense singlet oxygen (¹O₂) and activate photoprotection, enhancing high-light tolerance in plants and animals. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A groundbreaking 3D DNase-Enhanced Expression Profiling (3DEEP) captures hundreds of hair follicles' dynamics in neonatal mouse skin, advancing understanding of organogenesis. PMID:42385701, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00702-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Cysteine's sulfur divides paths between glutathione & iron-sulfur clusters, crucially influencing CD8+ T cell proliferation, function, & anti-tumor immunity. Fascinating! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Polyploidy is a major evolutionary force in angiosperms, with 132 ancient WGD events analyzed across 470 species, revealing non-random clustering. Fascinating! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Precision medicine's potential hinges on top-tier genome sequencing. Address key challenges: germline, tumor, cell-free DNA, genetic therapy standards. PMID:42387168, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10621-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Colorectal cancer liver metastases show striking heterogeneity: 5-year survival is <44.2% for 'replacement' vs. 73.4% for 'encapsulated.' No therapies yet. PMID:42386979, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10686-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting research: 34 circRNAs identified in blood for early Alzheimer's diagnosis. Predictive model matches plasma pTau217 effectiveness. PMID:42387213, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04485-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Malaria vaccine development struggles due to lack of T cell targets. Cross-stage, cross-species CD8⁺ T cell antigens identified for P. falciparum & P. vivax. PMID:42386975, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10730-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study discovers 7 de novo EHMT2 variants causing autosomal dominant Kleefstra syndrome. These reduce G9a methyltransferase activity, revealing new genetic insights. PMID:42386776, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74987-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study finds restoring cortical disinhibition reduces Huntington's symptoms. In-depth 2-photon imaging reveals roles of neuronal subtypes. HD movement disorder unravelled. PMID:42386967, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10671-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed a CRISPR knockout mouse library targeting 84 host genes for in vivo influenza A studies, paving the way for better understanding of viral pathogenesis. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila. Diallyl disulfide, a garlic compound, inhibits both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Targeted TFO liposome (tLipo-TFO1) reduces PAI-1, addressing pulmonary fibrosis by enhancing ECM clearance. PMID:42385711, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00326-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪