New study narrows the timeline for the emergence of life
www.uni-bayreuth.de/en/press-rel...
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The cGAS-STING pathway detects dsDNA, triggering immunity and responses to cell stress. It influences tissue health & antitumor effects while linking to inflammatory diseases. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG 🧪

Study reveals human hippocampal neurons exhibit shared semantic representations for bilinguals. "Cross-language neurons" correlate responses for equivalent words in English & Spanish. PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA 🧪

New study maps 89,000 gene interactions in HAP1 cells using CRISPR, revealing hierarchical modules linked to protein complexes and advancing gene co-essentiality insights. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Integrative structure of norovirus NS3 suggests a role in RNA transport
#virus #virology #RNA #MicroSky
@natcomms.nature.com
www.nature.com/articles/s41...

Systematic CRISPR screens in CD4+ T cells identified key pro- and anti-HIV host factors, revealing diverse antiviral mechanisms and potential therapeutic targets. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a conserved ZnF domain protein, to sense ¹O₂ and activate photoprotective responses, showcasing a novel mechanism for light tolerance. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on bridge-like lipid transfer! Cryo-EM reveals VPS13A interacting with XK, unraveling mechanisms of vesicle-independent lipid transfer between organelles. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk over 5 years ahead, aiding prevention. CANTOS showed IL-1β inhibition can reduce incidence, but NNT remains high. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

In SOD1-G93A mice, alpha motor neurons transition into a unique "disease-associated motor neuron" state before cell death, revealing 1000s of molecular changes! PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study shows prion-based switching in DNA repair proteins boosts mutagenesis in S. cerevisiae, enhancing adaptability across diverse environments. Evolutionary game-changer! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG 🧪

New research reveals two clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats, with one clade binding human ACE2, enhancing zoonotic transmission risk. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Researchers reconstituted human primitive streak formation by co-culturing ESCs with 3 extra-embryonic cell types, revealing their crucial role in tissue patterning and organization. PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA 🧪

Heat stress in mice elevates KLK14, linking skin to hypothalamic LRRC7+ astrocytes, increasing susceptibility to metabolic dysfunction on an obesogenic diet. A startling 50% of heated mice show worsened… PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #RNA 🧪

A blood-brain barrier-like vascular gate limits immune cell infiltration in small cell lung cancer (SCLC), hindering immunotherapy efficacy. SCLC shows distinct endothelial tightness, thickened basement… PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #RNA 🧪

A novel CRISPR-Cas9 mouse library targeting 84 host factors enhances in vivo screening for influenza A, bridging in vitro data gaps and boosting viral research. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of human fertilized eggs arrest in pre-implantation due to error-prone second mitotic divisions. PLK4 inhibition reduces centriole overduplication, improving development. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 plays a crucial role in safely reprogramming human somatic cells to pluripotency while balancing genome stability. This balancing act is key for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA 🧪

New data reveals that after bivalent CAR T cell therapy for recurrent GBM, prolonged survival was linked to the endogenous immune response; detailed profiling of CSF was key! PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in Duchenne muscular dystrophy using LEAPER 2.0! Circular arRNAs enable long-term exon skipping, reversing muscle degeneration in monkeys and humans. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪