Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation & chronic pain after repeated E. coli infections, linked to IL-6. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Interested in introducing undergraduate students to pharmacology research? Learn how to bring SURF to your campus! Deadline: October 1, 2026. https://ow.ly/ZePx50ZQjMT
#pharmsky 🧪

Interested in introducing undergraduate students to pharmacology research? Learn how to bring SURF to your campus! Deadline: October 1, 2026. https://ow.ly/ZePx50ZQjMT
#pharmsky 🧪

Unlocking genome regulation: A new method analyzes over 1.6M compositions, tests 653, & finds a buffer boosting mRNA by 20x for clearer gene expression insights. PMID:42364991, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74559-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A model reveals that geometric constraints significantly shape mammalian cortical connectomes, highlighting 3D connectivity's role in their complex architecture. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals hippocampal neurons link bilingual semantics—finding "cross-language neurons" responding similarly to words like "tierra" (spanish) and "earth" (english). PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of fertilized eggs stall in human pre-implantation. Imaging 150+ embryos shows the 2nd mitotic division has the highest errors. PLK4 inhibition can reduce centriole overduplication. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

New study reveals CD8+ T cell immunity enhances tumor sensitivity to cuproptosis, suggesting a link between copper-induced cell death and improved immunotherapy outcomes. PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Prion-based protein self-assembly enables rapid adaptive mutagenesis in Saccharomyces cerevisiae populations, altering DNA repair mechanisms for evolution. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP promotes membrane shearing, enhancing phage immunity via TM proteins in the CBASS system, revealing key antiviral mechanisms. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing RegVelo: a novel framework that bridges gene regulatory networks and RNA splicing dynamics, enhancing insights into cellular fate transitions via deep learning! #RegVelo PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA 🧪

Primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveal crucial totipotent-like features, advancing embryonic development modeling. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG 🧪

Transposable elements, making up nearly 50% of mammalian genomes, play key roles in shaping gene expression, evolution, and disease through locus-specific regulation. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New clades of SARS-CoV-2-related coronaviruses found in Thai horseshoe bats show ability to bind human ACE2; dynamic virology raises significant concerns! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel blood-brain barrier-like vascular gate in small cell lung cancer limits immune cell infiltration, explaining the poor immunotherapy response in SCLC. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a groundbreaking tool that integrates gene regulatory networks with RNA velocity, identifying 7 key regulators influencing cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale genetic interaction map from HAP1 cells reveals ~89,000 interactions, aligning genes into modules linked to protein complexes, advancing gene co-essentiality interpretation. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky 🧪

Study on 3,987,182 COVID-19 cases in Korea shows higher asthma risk post-infection for those with systemic atopy or upper-airway disease. Who else saw this connection? PMID:42364998, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74860-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Donor-derived CD19-CAR T cells show enhanced expansion & persistence vs. standard CAR T cells post-HSCT. TSCM cells yield complete responses at low doses, no lymphodepletion needed. PMID:42066750, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00383-1 #Medsky #Pharmsky #RNA 🧪

Researchers from Emory University Department of Medicine propose oleoylethanolamide may be the endogenous ligand for the orphan GPCR GPR3. It stimulates cAMP formation over hours and promotes recruitment of GPR3 to the cell surface thereby increasing signaling: https://ow.ly/sf7v50ZQ7hC #pharmsky 🧪