MAPK/ERK signaling enhances glioma immunotherapy via increased T cell infiltration an… PMID:42350396, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74124-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin induces neurotoxicity by activating NER in neurons, leading to cell death instead of protection. Insights challenge traditional views on DNA repair mechanisms. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel EMF-responsive gene switch enables precise in vivo control of gene expression, revealing Cyb5b's role as an EMF sensor via CRISPR-Cas9 screening. PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 311 brain samples reveals >1,000 somatic cancer variants in Alzheimer's microglia. These drive clonal expansion and inflammation, spotlighting links to cancer. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research using SAMENT highlights that metastatic niches show 50% macrophage enrichment and 30% T cell depletion, revealing organ-specific features in bone metastasis. PMID:42054994, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00398-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a game-changing framework linking gene regulatory networks to RNA velocity, identifying key regulators influencing cell fate changes. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replayed 100+ monoclonal GC reactions to quantify antibody evolution. Deep mutational scanning reveals key dynamics in B cell affinity competition. #ScienceInsights PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Teclistamab + daratumumab show promise in NDMM in phase 2. Initial results: deep responses but ongoing; watch for data! PMID:42350642, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04471-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switching of DNA repair proteins boosts mutagenesis in S. cerevisiae, enhancing adaptive evolution across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Autoantibodies identified in ~25% of long COVID patients may drive symptoms like pain, fatigue, and cognitive issues, highlighting the disease's complexity. PMID:42208496, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00511-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New cryo-EM structures reveal the 2:4:2 assembly of Wnt3a/Fzd8/LRP6 complexes, showing how Wnt3a homodimers engage Fzd and LRP6 for Wnt/β-catenin signaling! PMID:42202788, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neuronal state influences expression of psychiatric gene variants. A crucial piece for understanding mental health! 📘🧠 PMID:42348709, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aei6085 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Unveiling HIV secrets! Three immunoregulatory signatures in TSCM CD4⁺ T cells are key to non-productive HIV infection. A game changer in understanding HIV reservoirs! PMID:42350407, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74551-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study of 78,664 participants reveals >24,000 protein QTLs linked to 1,116 proteins, highlighting genetic influence on disease pathways and mechanisms. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals structures of human blue (OPN1SW) & green-sensitive cone opsins, aiding understanding of photopic vision mechanisms. PMID:42348698, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adz3624 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals mapping of olfactory receptors in MoE & OB using MERFISH, showing how social odors influence mouse behavior. Key insights on 100+ ORs! PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: NEDD8 & SUMO2 regulate skin cell functions oppositely. Knockout mice reveal roles in homeostasis & inflammation, using multiomics. PMID:42348677, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeb3900 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a conserved mediator with a ZnF domain, to sense singlet oxygen (¹O₂) and trigger photoprotection, enhancing high-light tolerance. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: Single-cell multiomics of neuron activation across 100 donors reveals key genetic variants for neuropsychiatric disorders. PMID:42348686, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adw3949 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transform lipid peroxidation: 4-ONE reprogrammed as a chemoselective crosslinker. Connects Cys-Lys, forming pyrrole linkage. Precision in oxidative stress chemistry! PMID:42350428, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74843-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪