New study reveals TMEM154/Galvanin acts as a cellular antenna, sensing electrical fields to guide cells' migration towards the cathode with precision. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🧬 From sequence to solution.
OTDC 2027 explores emerging advances in oligonucleotide therapeutics, RNA medicines, and innovative delivery technologies shaping the future of healthcare.

📅 May 11–12, 2027 | Boston, MA & Virtual
🔗 oligo-nucleotide.com
#OTDC2027 #RNA #DrugDelivery

🧬 Special Issue now complete — 10 papers published!

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition

Edited by Dr. Christopher U. T. Hellen.

👉Read the collection: www.mdpi.com/journal/viru...

#Virology #Translation #RNA

BRCA1-deficient environments find PARP inhibitor resistance from Shieldin subunits loss, Shld2/Shld3, but not 53BP1, in replication-coupled DSBs. How does Shieldin's precise role evolve? PMID:42374033, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74867-3 #Medsky #Pharmsky #RNA 🧪

Astronauts' plasma metabolomics (n=52) before, during, after ISS missions reveal microgravity boosts gut microbial protein fermentation, altering metabolism.🚀 PMID:42373641, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74979-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe reprogramming of human somatic cells to pluripotency, balancing genome stability with Yamanaka factors. Essential insights for safer cell fate manipulation! PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG 🧪

A groundbreaking LLM-assisted scoring framework identified GPNMB as a promising CAR T target for 3 cancers: melanoma, leukemia, and colorectal cancer. #CARtherapy PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel neural network, Deep-Phase, links cellular condensate morphology to biochemical processes, revealing how drugs induce structural changes. Fascinating insights! PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replaying 100+ monoclonal GC reactions reveals how B cell competition shapes antibody affinity evolution using deep mutational scanning, unlocking Darwinian dynamics in action. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Galvanin (TMEM154) is essential for guiding immune and epithelial cells in electric fields, crucial for rapid responses to tissue injury. Discovering its role unlocks insights into cell migration. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #RNA 🧪

Cysteine's sulfur partitioning impacts T cell fate: its routing fuels CD8⁺ T cell proliferation and anti-tumor immunity via glutathione and iron-sulfur synthesis! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing CANVAS: an AI platform that deciphers TME spatial architecture from H&E histopathology, built on 18M+ cells, advancing tumor ecology insights and therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Transposable elements make up nearly 50% of mammalian genomes, influencing gene expression and evolution. Recent studies show these elements play key regulatory roles, even if unable to mobilize. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #RNA 🧪

Spermatogenesis is mapped in 867,062 mouse testis cells, revealing 2,653 genes showing a cycle. Sertoli cells sync transcriptionally, advancing understanding of fertility. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new model reveals that the unique topology of mammalian cortical connectomes arises from physical constraints, with 90% of connections focused in specific regions. Insightful! PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG 🧪

A study reveals that >2700 human mRNA 3' UTRs with conserved nucleotides modulate protein activity, specifically by altering JMJD3 folding via its KDM6B 3' UTR. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

12 cave lion genomes from over 100,000 years reveal distinct evolutionary lineages from modern lions, showcasing unique variants & ancient gene flow between them. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives chronic pain from E. coli infections. IL-6 signaling boosts this process, linking stress to persistent sensory dysfunction. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #RNA 🧪

Too Much RNA Can Drain a Cell’s Energy, Scientists Discover

cc @nanoappsmedical.bsky.social @cellrep7.bsky.social @amandascott2023.bsky.social
#NanoApps #Research #SDGs #GHCE #Science #RNA #EnergyScience #Discovery #DrainCellEnergy
www.nanoappsmedical.com/too-much-rna...

New study narrows the timeline for the emergence of life
www.uni-bayreuth.de/en/press-rel...
#BGI #UniBayreuth #UBT #RNA #Leben #EntstehenDesLebens #Forschung