RegVelo merges gene regulatory dynamics with RNA velocity, enabling deeper insights into cell fate transitions by modeling splicing kinetics and GRN interactions. PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits identified garlic as a strong mating & egg-laying deterrent in Drosophila, with diallyl disulfide inhibiting these behaviors. Fascinating! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

This study reveals that p21+ senescent cells play distinct roles in BBB and CSF barrier development in mice, with lifelong non-inflammatory states in choroid plexus vital for CSF production. PMID:42269604, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00581-7 #Medsky #Pharmsky 🧪

New insights on polyploidy reveal 132 ancient whole-genome duplications across 470 angiosperm species, showcasing non-random clustering during environmental upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New trimodal platform combines in vivo Ca²+ imaging, single-neuron morphology, and transcriptomics, enabling comprehensive insights into neuronal functions! PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals variant rs17437411 in the HOXA locus links to lower blood counts & cancer protection, disrupting a novel lncRNA (HOXA opposi), influencing hematopoietic stem cells. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Exciting progress in DMD treatment: long-term reversal achieved via circ-arRNA-guided exon skipping in monkeys and humans, leveraging ADAR for effective RNA editing! #DMD PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe human somatic cell reprogramming toward pluripotency, balancing genome stability with Yamanaka factors for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 1,025 species reveals that early unicellular genomes were random; evolution led to structured "global folding" & "checkerboard" formations in complex life. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, suggesting a possible single-sex population. Fascinating! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, while effective against cancer, induces neuronal death via nucleotide excision repair (NER), which instead of protecting neurons, contributes to their vulnerability. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Single-cell mapping of DNA-protein interactions via D&D-seq reveals insights into transient TF bindings, enhancing understanding of gene regulation at single-cell resolution. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new non-invasive genetic system reveals that brain protein clearance follows unique routes to CSF, uncovering drainage hotspots often missed by traditional tracers. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel experimental model reenacted 100+ monoclonal germinal center (GC) reactions, revealing insights into B cell competition and affinity maturation dynamics. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

In our recent Editor's Choice, research supports dietary glycine potential as a safe strategy for autoimmune hepatobiliary and pancreatic diseases. Learn more about the research from the team at Juntendo University Graduate School of Medicine: https://ow.ly/YSpW50ZQZE1
#pharmsky 🧪

New findings reveal that macrometastases in breast cancer activate a Metastatic Trabecular Morphogenesis (MTM) program, leveraging developmental pathways for expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover life science tools with bio.tools: a registry offering easy access and metadata for 15K+ software solutions. ✨ Search smarter! PMID:42363751, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag420 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation & chronic pain after repeated E. coli infections, linked to IL-6. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Interested in introducing undergraduate students to pharmacology research? Learn how to bring SURF to your campus! Deadline: October 1, 2026. https://ow.ly/ZePx50ZQjMT
#pharmsky 🧪

Interested in introducing undergraduate students to pharmacology research? Learn how to bring SURF to your campus! Deadline: October 1, 2026. https://ow.ly/ZePx50ZQjMT
#pharmsky 🧪