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12 cave lion genomes (over 100,000 years old) reveal modern and cave lions as distinct lineages with unique traits and ancient gene flow between them. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Human hippocampal ripples adjust cortical responses based on predicted uncertainty, optimizing brain info encoding. PMID:42350816, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02345-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies TMEM154/Galvanin as a key receptor that allows cells to sense electric fields, guiding movement toward the cathode. #CellMigration #Therapeutics PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR-Cas9 mouse library targeting 84 host factors revolutionizes influenza research, enabling in vivo validation and deeper insights into viral pathogenesis! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough: Cryo-EM reveals structures of human LWS-, MWS-, and SWS-opsins with G protein, decades after rhodopsin. Stunning insights! PMID:42348690, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adz8141 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits & veggies found garlic effective against mating & egg laying in Drosophila. Diallyl disulfide deters both behaviors! 🧄🐞✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Small cell lung cancer (SCLC) features a unique blood-brain barrier-like vascular gate that limits immune cell infiltration, explaining poor immunotherapy responses. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI enhances CAR T therapy by identifying GPNMB as a promising target in melanoma (up to 50% response), leukemia, and colorectal cancer, streamlining target selection. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Lariat RNA debranching by DBR1 enzyme prevents 21- & 22-nt lasiRNA production, avoiding… PMID:42348705, Science 2026, @ScienceMagazine @OTSociety @NAR_Open https://doi.org/10.1126/science.aeb4938 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal that microtubule-associated protein 1B (MAP1B) shuttles to the nucleus of neural stem cells, suggesting its role in cell fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A breakthrough study maps 379 cell types in whole-mouse sections using spatiotranscriptomics, analyzing 59M single cells for precise histological insights! PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

B cell deficiency reduces TGF-β1 during exercise, impairing liver glutamate metabolism and decreasing blood/muscle glutamate, limiting exercise capacity. PMID:41999743, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur is crucial for T cell fate, directing 80% to glutathione and 20% to iron-sulfur clusters, vital for CD8⁺ T cell growth and anti-tumor immunity! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals p21+ senescent cells shape blood-brain and blood-CSF barriers in mice, with lifelong non-inflammatory states in choroid plexus supporting CSF production. PMID:42269604, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00581-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

📢 New ESHG–ISPD recommendations on prenatal genomic sequencing

📖 Read the full article in the European Journal of Human Genetics: www.nature.com/articles/s41...

MARCH7 identified as a key E3 ubiquitin ligase that safeguards against ferroptosis by regulating intracellular Fe homeostasis via NCOA4 ubiquitylation. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neoadjuvant stereotactic body radiation therapy (3×8 Gy) with durvalumab and oleclumab shows promise in ER+HER2- early breast cancer. PMID:42350643, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04453-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

MAPK/ERK signaling enhances glioma immunotherapy via increased T cell infiltration an… PMID:42350396, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74124-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin induces neurotoxicity by activating NER in neurons, leading to cell death instead of protection. Insights challenge traditional views on DNA repair mechanisms. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel EMF-responsive gene switch enables precise in vivo control of gene expression, revealing Cyb5b's role as an EMF sensor via CRISPR-Cas9 screening. PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪