A study of 1,025 species reveals that early genomes were random, evolving into organized "global folding" and "checkerboard" architectures in plants, shaping spatial regulation. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG 🧪

~50% of fertilized human eggs arrest in pre-implantation. Key findings show 2nd mitotic divisions are error-prone; centriole overduplication can be suppressed by PLK4 inhib. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Zebrafish study reveals oligodendrocytes use Gephyrin to myelinate GABAergic axons, regulating myelin sheath growth. Key insights into neuron circuit tuning! PMID:42373637, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74902-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New VIS-seq method reveals effects of ~3,000 LMNA & PTEN variants, capturing complex phenotypes in cell structure and protein dynamics. Insights could transform understanding of genetic variation! PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #RNA 🧪

Discoveries unveil that while Hepatitis C virus (HCV) uses 5' FAD caps on RNAs, Norway rat hepacivirus 1 employs 5' NAD caps, showing evolutionary divergence in hepaciviruses. PMID:42373660, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74886-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel model replayed 100+ monoclonal GC reactions, revealing how B cell affinity dynamics shape antibody evolution post-antigen exposure. Insights gained on affinity progression! PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG 🧪

A groundbreaking study maps 10+ senescence cell states across human tissues using single-cell, spatial multi-omics, revealing unique senotypes and tissue-specific programs for advancing senotherapeutics. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #RNA 🧪

AI in neurology: FDA approved 42+ algorithms, but real-world impact lags. Bridging research-clinic gap is key. PMID:42373953, Nat Rev Neurol 2026, @NatRevNeurol https://doi.org/10.1038/s41582-026-01225-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: TBI is linked to dementia risk. Plasma p-tau217/Aβ42 ratio is 90% accurate for detecting brain amyloid in veterans, even with TBI history. Share your thoughts! PMID:42371653, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2042 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing RiboArena 🧬 An interactive leaderboard for RNA 3D structure prediction. Compare model accuracy, structural quality, and runtime. We plan to update it weekly—explore the results and share your feedback!
isyslab-hust.github.io/ribo-arena/
#RNA #StructuralBiology

Over 2,700 human mRNA 3' UTRs with conserved nucleotides regulate protein activity, shaping the folding of IDR-rich proteins like JMJD3, impacting function over abundance. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Galvanin (TMEM154) emerges as a pivotal sensor for electric-field-guided migration, essential for immune and epithelial cells' rapid response to injury, revealing a 1st step in healing! PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA 🧪

🚀 Ribo-INK is launching!
Join the inaugural meeting of the Lyon-Grenoble interdisciplinary RNA community.
📅 18 Nov 2026 | 10:00–15:00
📍 ENS Lyon
🎤 Keynote: Phillip D. Zamore
Short talks, flash talks & lunch.
🎟️ Free for academics; registration required:
ribo-ink.fr/next-meeting/
#RNA #RNASalon

Our new review in Current Opinion in Structural Biology is out!

We discuss how multicolour #SingleMolecule imaging reveals gene expression in action - from #Transcription and #RNA processing to #Translation, molecular coupling, and live-cell tracking.

doi.org/10.1016/j.sb...

#smFRET @embl.org

Discover how a rapid CIU assay predicts agonism in hIgG2 mAb variants by analyzing gas-phase unfolding and hinge-engineering, revolutionizing antibody design. PMID:42373639, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75137-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Xenophagocytosis by host macrophages hinders interspecies chimerism in organ transplantation. Blocking this could boost xenogeneic cell engraftment, a major breakthrough! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RegVelo bridges RNA velocity and gene regulatory networks, modeling cellular dynamics with splicing kinetics to reveal mechanisms behind cell fate transitions—defining 1 path to deeper insights. PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #RNA 🧪

A genome-scale map reveals ~89,000 high-confidence gene interactions in HAP1 cells, organizing genes into hierarchical modules, crucial for targeted therapies. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals TMEM154/Galvanin acts as a cellular antenna, sensing electrical fields to guide cells' migration towards the cathode with precision. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🧬 From sequence to solution.
OTDC 2027 explores emerging advances in oligonucleotide therapeutics, RNA medicines, and innovative delivery technologies shaping the future of healthcare.

📅 May 11–12, 2027 | Boston, MA & Virtual
🔗 oligo-nucleotide.com
#OTDC2027 #RNA #DrugDelivery