50% of human fertilized eggs arrest in pre-implantation due to error-prone second mitotic divisions. PLK4 inhibition reduces centriole overduplication, improving development. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 plays a crucial role in safely reprogramming human somatic cells to pluripotency while balancing genome stability. This balancing act is key for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA 🧪

New data reveals that after bivalent CAR T cell therapy for recurrent GBM, prolonged survival was linked to the endogenous immune response; detailed profiling of CSF was key! PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in Duchenne muscular dystrophy using LEAPER 2.0! Circular arRNAs enable long-term exon skipping, reversing muscle degeneration in monkeys and humans. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cellular senescence shows diverse states across tissues in aging and disease, revealing 40+ senotypes and enabling targeted therapies via AI-driven multi-omics insights. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AD brain analysis of 311 samples revealed >1,000× sSNVs in cancer driver genes, linked to clonal hematopoiesis, driving expansion in microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting advancements in RNA editing with LEAPER 3.0! Engineered ADAR-recruiting RNAs enhance precision and efficiency by using AlphaFold 3 structure insights. Future of gene therapy? PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA 🧪

AI-driven discovery of GPNMB CAR T cells reveals a novel multi-cancer therapy, refining targets with single-cell RNA seq from 1k+ human samples. Exciting progress! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing in bacteria, revealing how cyclic-oligonucleotide signaling boosts antiviral defenses via 3TM effectors. Key insights into immunity mechanisms unveiled! PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying key regulators influencing cell fate shifts. A game changer in cell-state prediction! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain enhance sustained attention, challenging the role of cholinergic neurons! PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin causes neuronal death by activating nucleotide excision repair (NER), which paradoxically promotes damage instead of protecting neurons. #Neurotoxicity PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings show that allergens trigger PAR1-dependent ferritinophagy, raising intracellular iron levels, crucial for noncanonical GSDMD activation in allergic airway diseases. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A study on NSCs reveals that MAP1B, a microtubule-associated protein, shuttles to the nucleus, linking cytoskeletal dynamics to transcriptional regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered GMPs enable long-term expansion of mouse and human progenitors for tumor immunotherapy, powered by myeloperoxidase's role in proliferation. Transformative! PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel pooled imaging method, VIS-seq, analyzed ~3,000 LMNA & PTEN variants, uncovering high-dimensional phenotypic profiles linked to protein behavior and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism via its virulence factor to thrive in the inflamed gut, fueling oxidative growth in the large intestine and linking to colitis & CRC. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing D-SPIN: a novel framework that reconstructs gene regulatory networks from single-cell RNA-seq data, unveiling 9 key organizing principles for cellular responses to perturbations! PMID:42127893, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0 #Medsky #Pharmsky 🧪

Cells can detect and navigate electrical fields via the receptor TMEM154/Galvanin, guiding movement toward the cathode. A breakthrough in cell migration studies! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RegVelo merges gene regulatory dynamics with RNA velocity, enabling deeper insights into cell fate transitions by modeling splicing kinetics and GRN interactions. PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪