Systematic screens in primary human CD4+ T cells identified 50+ pro- and anti-HIV factors. CRISPRa revealed key antiviral mechanisms enhancing resistance to HIV. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 12 cave lion genomes from >100,000 years show they were distinct from modern lions, with unique variants & evidence of ancient gene flow! PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI for spatial tumor profiling from 18M+ cells in H&E histopathology, revealing TME's influence on disease progression & therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that macrometastases in breast cancer utilize a 3D morphogenetic process, activating a gene program that mimics developmental branching, promoting expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal that human mRNA 3' UTRs, found in over 2,700 genes, regulate protein activity by co-translationally influencing IDR folding, as seen with JMJD3. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk over 5 years prior to diagnosis, enhancing prevention strategies and addressing high NNT from IL-1β inhibition. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

B cell deficiency impacts exercise capacity by reducing TGF-β1, which disrupts hepatic glutamate metabolism, leading to decreased blood & muscle glutamate. PMID:41999743, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Polyploidy plays a vital role in angiosperm evolution. Analyzing 470 species, 132 ancient whole-genome duplication events showed surprising non-random clustering patterns. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals >1,000× sequencing of 311 brains shows somatic cancer variants in AD brains, enriching clonal hematopoiesis. Microglia-like cells exhibit clonal expansion. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New yeast toolbox enables precise cell-cell adhesion in synthetic communities, improving bioproduction by targeting 7 genes in strain 007Δ! PMID:41491832, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-025-02081-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Research uncovers Srr2's role in controlling SOX2 levels, shaping chromatin & transcription in neu… PMID:42351220, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-04126-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing via 3TM proteins, enhancing broad phage immunity through CBASS, revealing crucial details about viral defense mechanisms in prokaryotes. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A defined co-culture system reveals how embryonic stem cells (ESCs) interact with extra-embryonic tissues, crucial for human gastrulation and embryonic organization. PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that 2'3'-cGAMP induces membrane shearing via 3TM proteins, enhancing phage immunity in prokaryotes, advancing understanding of antiviral mechanisms. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens reveals no male markers, suggesting a sample population from a single sex. #HomoNaledi #Paleoproteomics PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Anopheles stephensi, an urban malaria threat to 126M Africans, originated from a South Asian strain to Djibouti, as shown in 645 genomes. PMID:42348676, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adx6925 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Aging disrupts tissue homeostasis via mesenchymal drift, where cells lose lineage identity and gain mesenchymal traits, integrating and amplifying the hallmarks of aging. PMID:42208498, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00455-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Learning reshapes the neural geometry of the primate PFC, evolving from exploring diverse rules to efficiently encoding task-relevant info. PMID:42350815, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02333-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metabolomics and metagenomics of 4,336 plasma samples from 1,714 cancer patients reveal metabolic determinants for immune-checkpoint inhibitor outcomes! PMID:42350644, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04481-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows clade Ia monkeypox virus spreads efficiently through sexual contact. Investigates shedding and transmission in prairie dogs. Key data for outbreak control! PMID:42350436, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74578-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪