Revolutionizing neuroscience, a new trimodal platform reveals Ca²⁺ dynamics, morphology, and gene expression in single neurons for enhanced understanding of neuronal functions. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG 🧪

Chronic suppression of MDR Pseudomonas aeruginosa in a prosthetic joint infection achieved via personalized bacteriophage treatment after antibiotics failed! PMID:42364990, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74326-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel LLM-assisted scoring framework identifies GPNMB as a promising CAR T target in melanoma, leukemia, and colorectal cancer, addressing a key bottleneck in therapy. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies TMEM154/Galvanin as a key receptor enabling cells to sense electric fields (≤ 100 mV/mm) and migrate toward the cathode. Exciting times! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing spermatogenesis studies, 2,653 genes in 867,062 mouse testis cells reveal dynamic cycles in Sertoli cells, aligning transcription with germ-cell differentiation. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Aging male mice show disrupted water balance/thermoregulation: AVP neurons in hypothalamus are key. RNA-seq finds Avp upregulated. Old neurons enlarged, more excitable. PMID:42364986, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74819-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA locus lowers blood counts, protects against blood cancers, and alters phenotypes, linked to a new lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive vascular integrity in small-cell lung cancer leads to immune desertification. Wang et al. propose "reverse normalization" to enhance immunotherapy efficacy. PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research shows heat stress in mice elevates KLK14, leading to metabolic dysfunction on an obesogenic diet. Heat stress affects 1 in 3 mice’s metabolic health! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host gut metabolism using its Bacteroides fragilis toxin, fostering an oxidative environment that promotes its growth amid inflammation. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered ADAR-recruiting RNAs (arRNAs) boost RNA editing by leveraging endogenous ADAR, with LEAPER 3.0 enhancing precision via AlphaFold 3 insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA gene locus links to reduced blood counts, cancer protection, and impacts on human hematopoietic stem cells via a novel lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Largest proteogenomic study (n=78,664) reveals >24,000 protein QTLs linked to 1,116 proteins, uncovering pathways and genetic effects on disease mechanisms. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study links autoantibodies (AABs) to neurological symptoms in long COVID, revealing AABs against CNS and PNS proteins in patients—suggesting a causal role. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Want to make meaningful connections at #ASHG26? Register for the Know Before You Go webinar (Oct. 7, 12 pm U.S. ET) to learn where networking opportunities happen & how to make the most of them. Bring your questions for a live Q&A. Secure your spot: https://bit.ly/3VdApJ3 #ASHG

Enterotoxigenic Bacteroides fragilis (ETBF) rewires host metabolism using its toxin to thrive in the inflamed gut, revealing potential targets for colitis and cancer prevention. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel method, VIS-seq, measures diverse phenotypic effects of ~3,000 LMNA & PTEN variants, revealing complex impacts on protein activity and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel non-invasive genetic system reveals unique drainage routes for neuron-derived proteins from the brain to CSF, uncovering overlooked clearance hotspots. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, a cancer treatment, induces neurotoxicity. NER helps neurons remove DNA damage but paradoxically leads to cell death. Understanding this may aid neuroprotection. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪