New research maps 379 cell types across whole mouse sections using 59M single cells, enabling spatiotranscriptomics and machine learning for vital biomedical insights! PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Early-stage Alzheimer’s model: 5xFAD mice show cognitive inflexibility before memory issues, with hyperactive corticostriatal circuits and striatal cholinergic dysfunction. PMID:42362551, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74817-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Ferroptosis inhibition enhances graft function in liver and lung transplants. FXT-001 targets early lipid peroxidation post-ischemia-reperfusion injury. Key! PMID:42105762, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00459-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative design of G_i-biased CB1 agonists, LZD503 & LZD505, targets pain relief while minimizing side effects, paving the way for safer non-opioid therapies. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative evolution model replays 100+ monoclonal germinal center reactions, revealing that B cell competition drives affinity increases in antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

UPRmt in human microglia disrupts neuron-glia communication & promotes cell aging, revealing new insights into brain stress. PMID:42362883, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02320-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights show that vulnerable motor neurons in ALS shift to a unique "disease-associated" state marked by thousands of molecular changes before cell death. 📉🔍 PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how dynamic ACh signaling in the BLA, crucial for salience processing, links to NAc: D1 neurons promote & D2 neurons suppress! PMID:42362886, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02353-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new AI framework identifies GPNMB as a promising CAR T target across melanoma, leukemia, and colorectal cancer, tackling the challenge of safe therapeutic design. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, integrating gene regulatory networks with RNA velocity to reveal 100+ candidate regulators that shape cell fate transitions. Exciting advancements! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila, with diallyl disulfide leading the way! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 enhances RNA editing by using designed ADAR-recruiting RNAs (arRNAs) for precise, efficient editing. Advances in AlphaFold 3 structure unlock new strategies! PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how GCN5-related N-acetyltransferases creatively modify mature lasso peptides, introducing iterative acylation to enhance diversity! PMID:41826761, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02149-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

African populations hold 40% of human genetic diversity but are only 2% of genomic studies. Advocate for national genome projects to improve healthcare equity! PMID:42342701, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74952-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Osteosarcoma develops in juvenile metaphysis. Study shows p21 induction due to DNA damage in 3-5 immature osteoblast stages; 10-stage maturity path identified. PMID:42363015, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74929-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear envelope budding (NEB) permits the export of large RNA transcripts during myoblast differentiation into myotubes, revealing a vital role in cellular processes. PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals that prion-based switches in S. cerevisiae enhance mutagenesis, enabling rapid adaptation in diverse environments. Key to evolution! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative study tests 3KO porcine kidneys with 4 HTG combos. Results show promise: longer survival in primates, advancing xenotransplantation potential! 🌍👥 PMID:42362566, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74933-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Multiomic study reveals glutaminolysis enhances immune memory via lysine deacetylase inhibitors, boosting vaccine efficacy for high-risk groups like the elderly. PMID:42362565, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74866-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic screens in primary human CD4+ T cells identified 50+ pro- and anti-HIV factors. CRISPRa revealed key antiviral mechanisms enhancing resistance to HIV. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪