Polyploidy is a key force in angiosperm evolution, with 132 ancient whole-genome duplication events identified across 470 species, revealing non-random clustering—fascinating! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG 🧪

BsAb EVs target FAP⁺ fibroblasts in 1 surgical model, redirecting T cells to reduce epidural fibrosis effectively post-surgery. Potential game-changer for recovery! PMID:42364978, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74883-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

T cell activation triggers ADAM17-mediated cleavage via a 15-aa motif, enabling control over CAR expression. This innovation reduces CAR levels based on tonic signaling. PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies E3 ubiquitin ligase MARCH7 as a crucial ferro-guardian against ferroptosis, regulating iron homeostasis by targeting NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway senses dsDNA, linking innate immunity and cellular responses. Key to antitumor immunity, it also drives inflammatory disorders. #Immunology #Research PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Splenic macrophage-B cell axis in cerebral malaria drives systemic autoimmunity. CD36 autoantibodies, found in 97% of patients, target infected RBCs, causing pathological effects. PMID:42364976, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74882-4 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel library of 84 CRISPR-Cas9 mouse lines enables in vivo screening of host factors in influenza A research, overcoming bottlenecks in functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Recent findings reveal that MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to gene regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Cysteine's sulfur is crucial for CD8⁺ T cell fate, driving 60% toward glutathione and 40% for iron-sulfur clusters, influencing proliferation and anti-tumor immunity. PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery identifies GPNMB CAR T cells as a promising multi-cancer therapy, refining targets through single-cell RNA seq from 100+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Exploring SMVT with cryo-EM: 3 structures unveiled—occluded, outward-open, inward-open—reveal how it transports vital vitamins. Key to tackling its dysfunction! PMID:42364996, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74948-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NAD+ modulates mitochondrial vulnerability in MERTK models of retinitis pigmentosa (R… PMID:42365006, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74400-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Major breakthrough in HIV research: CRISPR screens in primary CD4+ T cells identified multiple pro- and anti-HIV host factors, revealing diverse antiviral mechanisms! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@clare-turnbull.bsky.social & colleagues of @ajhgnews.bsky.social latest article presents CanVar-UK, an international data-sharing and variant interpretation platform for cancer susceptibility genes: https://www.cell.com/ajhg/abstract/S0002-9297(26)00307-1 #ASHG #HumanGenetics #GeneticsDiscoveries

🚨Tomorrow at 9:30 am (U.S. ET), we'll be diving into the future of #humangenetics.

Join leading experts for two days of #AI & #machinelearning insights & panel discussions shaping genomics and #precisionmedicine.
Don't miss this ➡️ Register now: https://bit.ly/4pLrGt7 #ASHG

Chloroplasts use MBS1 to sense singlet oxygen (¹O₂) and trigger photoprotection, revealing how plants manage high-light tolerance through protein condensates. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veggies reveals garlic as a potent inhibitor of mating & egg-laying in Drosophila. Diallyl disulfide shows promise in pest control! 🧄✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Intranasal boost in female mice primed with Wuhan-1 spike mRNA or ChAd vaccines enhances variant-specific antibodies, addressing immunity evasion in emerging SARS-CoV-2 variants. PMID:42364994, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74762-x #Medsky #Pharmsky #RNA #ASHG 🧪

Revolutionizing neuroscience, a new trimodal platform reveals Ca²⁺ dynamics, morphology, and gene expression in single neurons for enhanced understanding of neuronal functions. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG 🧪

Chronic suppression of MDR Pseudomonas aeruginosa in a prosthetic joint infection achieved via personalized bacteriophage treatment after antibiotics failed! PMID:42364990, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74326-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪