Galvanin (TMEM154) emerges as a pivotal sensor for electric-field-guided migration, essential for immune and epithelial cells' rapid response to injury, revealing a 1st step in healing! PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA 🧪

Discover how a rapid CIU assay predicts agonism in hIgG2 mAb variants by analyzing gas-phase unfolding and hinge-engineering, revolutionizing antibody design. PMID:42373639, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75137-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Xenophagocytosis by host macrophages hinders interspecies chimerism in organ transplantation. Blocking this could boost xenogeneic cell engraftment, a major breakthrough! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale map reveals ~89,000 high-confidence gene interactions in HAP1 cells, organizing genes into hierarchical modules, crucial for targeted therapies. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals TMEM154/Galvanin acts as a cellular antenna, sensing electrical fields to guide cells' migration towards the cathode with precision. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur plays a crucial metabolic role in T cells, channeling resources between glutathione and iron-sulfur clusters, driving CD8⁺ T cell proliferation and anti-tumor immunity! 🚀 PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky 🧪

BRCA1-deficient environments find PARP inhibitor resistance from Shieldin subunits loss, Shld2/Shld3, but not 53BP1, in replication-coupled DSBs. How does Shieldin's precise role evolve? PMID:42374033, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74867-3 #Medsky #Pharmsky #RNA 🧪

Introducing CANVAS: an AI-powered tool that decodes tumor microenvironments from 18M cells in H&E histopathology, revealing critical insights for cancer progression and therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky 🧪

Astronauts' plasma metabolomics (n=52) before, during, after ISS missions reveal microgravity boosts gut microbial protein fermentation, altering metabolism.🚀 PMID:42373641, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74979-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain are key for sustaining attention, challenging previous beliefs about cholinergic neurons' role. PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky 🧪

p53 is crucial for safe reprogramming of human somatic cells to pluripotency, balancing genome stability with Yamanaka factors. Essential insights for safer cell fate manipulation! PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG 🧪

A groundbreaking LLM-assisted scoring framework identified GPNMB as a promising CAR T target for 3 cancers: melanoma, leukemia, and colorectal cancer. #CARtherapy PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel neural network, Deep-Phase, links cellular condensate morphology to biochemical processes, revealing how drugs induce structural changes. Fascinating insights! PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replaying 100+ monoclonal GC reactions reveals how B cell competition shapes antibody affinity evolution using deep mutational scanning, unlocking Darwinian dynamics in action. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Join ASPET for a webinar designed for students exploring graduate studies in pharmacology, open to BOTH members and non-members! Faculty and graduate students from Boston University will share what to expect from their pharmacology training program: https://ow.ly/rsqw50ZR5k3
#pharmsky 🧪

Join ASPET for a webinar designed for students exploring graduate studies in pharmacology, open to BOTH members and non-members! Faculty and graduate students from Boston University will share what to expect from their pharmacology training program: https://ow.ly/rsqw50ZR5k3
#pharmsky 🧪

Cysteine's sulfur partitioning impacts T cell fate: its routing fuels CD8⁺ T cell proliferation and anti-tumor immunity via glutathione and iron-sulfur synthesis! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing CANVAS: an AI platform that deciphers TME spatial architecture from H&E histopathology, built on 18M+ cells, advancing tumor ecology insights and therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Spermatogenesis is mapped in 867,062 mouse testis cells, revealing 2,653 genes showing a cycle. Sertoli cells sync transcriptionally, advancing understanding of fertility. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new model reveals that the unique topology of mammalian cortical connectomes arises from physical constraints, with 90% of connections focused in specific regions. Insightful! PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG 🧪