New study reveals TRPC4/5 channels key to tFUS effects in mice's retrosplenial cortex, reducing sensitivity and activating early growth response. Exciting progress! PMID:42373633, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74779-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nur77 boosts NK cells against hepatocellular carcinoma by improving penetration and overcoming immunosuppression. Key role identified via spatial and single-cell transcriptomics. PMID:42374019, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75027-3 #Medsky #Pharmsky #RNA #ASHG 🧪

#Medsky🧪 #IDsky #pharmsky #publichealth #vaccinesmater #LongCOVID is an ongoing health condition that may occur after being infected with the #SARSCoV2 virus.🦠 can still be detected in the bodies of some people with LC.
🧪A clinical trial for LC found that treating patients

A study reveals that macrometastatic outgrowth in breast cancer employs a 3D morphogenetic process, activating a gene program similar to developmental branching to form structures efficiently. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky 🧪

Cisplatin, while effective for cancer, triggers neuronal death via nucleotide excision repair (NER). Unlike in dividing cells, NER in neurons enhances vulnerability to damage. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

A study of 1,025 species reveals that early genomes were random, evolving into organized "global folding" and "checkerboard" architectures in plants, shaping spatial regulation. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG 🧪

A study on recurrent GBM reveals that endogenous immune responses significantly influence outcomes post CAR T cell therapy, with some patients showing tumor reduction and extended survival. PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky 🧪

~50% of fertilized human eggs arrest in pre-implantation. Key findings show 2nd mitotic divisions are error-prone; centriole overduplication can be suppressed by PLK4 inhib. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Zebrafish study reveals oligodendrocytes use Gephyrin to myelinate GABAergic axons, regulating myelin sheath growth. Key insights into neuron circuit tuning! PMID:42373637, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74902-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discoveries unveil that while Hepatitis C virus (HCV) uses 5' FAD caps on RNAs, Norway rat hepacivirus 1 employs 5' NAD caps, showing evolutionary divergence in hepaciviruses. PMID:42373660, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74886-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel model replayed 100+ monoclonal GC reactions, revealing how B cell affinity dynamics shape antibody evolution post-antigen exposure. Insights gained on affinity progression! PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG 🧪

AI in neurology: FDA approved 42+ algorithms, but real-world impact lags. Bridging research-clinic gap is key. PMID:42373953, Nat Rev Neurol 2026, @NatRevNeurol https://doi.org/10.1038/s41582-026-01225-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The JPET section "Clinical Pharmacology" has been established to underscore the critical role that clinical pharmacology plays in advancing human health. Learn more and contribute your research: https://ow.ly/JbVi50ZFOPE
#pharmsky 🧪

The JPET section "Clinical Pharmacology" has been established to underscore the critical role that clinical pharmacology plays in advancing human health. Learn more and contribute your research: https://ow.ly/JbVi50ZFOPE
#pharmsky 🧪

Study: TBI is linked to dementia risk. Plasma p-tau217/Aβ42 ratio is 90% accurate for detecting brain amyloid in veterans, even with TBI history. Share your thoughts! PMID:42371653, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2042 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Over 2,700 human mRNA 3' UTRs with conserved nucleotides regulate protein activity, shaping the folding of IDR-rich proteins like JMJD3, impacting function over abundance. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Galvanin (TMEM154) emerges as a pivotal sensor for electric-field-guided migration, essential for immune and epithelial cells' rapid response to injury, revealing a 1st step in healing! PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA 🧪

Discover how a rapid CIU assay predicts agonism in hIgG2 mAb variants by analyzing gas-phase unfolding and hinge-engineering, revolutionizing antibody design. PMID:42373639, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75137-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Xenophagocytosis by host macrophages hinders interspecies chimerism in organ transplantation. Blocking this could boost xenogeneic cell engraftment, a major breakthrough! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale map reveals ~89,000 high-confidence gene interactions in HAP1 cells, organizing genes into hierarchical modules, crucial for targeted therapies. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪