Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered ADAR-recruiting RNAs (arRNAs) boost RNA editing by leveraging endogenous ADAR, with LEAPER 3.0 enhancing precision via AlphaFold 3 insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA gene locus links to reduced blood counts, cancer protection, and impacts on human hematopoietic stem cells via a novel lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Largest proteogenomic study (n=78,664) reveals >24,000 protein QTLs linked to 1,116 proteins, uncovering pathways and genetic effects on disease mechanisms. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study links autoantibodies (AABs) to neurological symptoms in long COVID, revealing AABs against CNS and PNS proteins in patients—suggesting a causal role. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel method, VIS-seq, measures diverse phenotypic effects of ~3,000 LMNA & PTEN variants, revealing complex impacts on protein activity and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel non-invasive genetic system reveals unique drainage routes for neuron-derived proteins from the brain to CSF, uncovering overlooked clearance hotspots. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin, a cancer treatment, induces neurotoxicity. NER helps neurons remove DNA damage but paradoxically leads to cell death. Understanding this may aid neuroprotection. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Large models like GPT-5 & Gemini show promise in health AI but can falter under simple stress tests, revealing key growth areas. PMID:42362863, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04501-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Check out PlanarFold: a new RNA model boosting simulation speed by over 10,000x with 2D coarse-grained dynamics, offering insights into RNA structures & dynamics! PMID:42362537, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74729-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rational discovery led to small-molecule PAK1 activators, revealing a novel site for autoinhibition release, advancing cardiac therapy prospects. PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Re-admin of AAV1-hOTOF gene therapy, even amid peak NAb titers in Otof^-/- mice, improves OTOF-related deafness outcomes. PMID:42362868, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04505-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cliramitug's long-term follow-up in trial NI006-101 shows lasting safety and efficacy with dose-dependent amyloid reduction in ATTR-CM patients over 12 months. PMID:42362866, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04487-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Late embryonic skin injuries can regenerate diverse tissues effectively, but this capacity diminishes post-birth, leading to hyperinnervation and incomplete healing. PMID:41864207, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00234-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies MARCH7 as a key E3 ubiquitin ligase that stabilizes iron homeostasis, reducing ferroptosis via K48-linked ubiquitylation of NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows that accumbal dopamine predicts preference: 2 types of reward cues trigger DA transients in 100% cases, declining at natural rewards and persisting with drugs. PMID:42362884, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02331-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Humans evaluate info by relative evidence, not absolute uncertainty. AI models predict behavior. Fascinating insights! 🌟 PMID:42362882, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02342-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new CRISPR knockout mouse library (84 lines) enables in vivo screening of host factors in influenza A research, bridging gaps in translation from in vitro studies. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A recent Cell study reveals autoantibodies in 25% of long COVID patients drive symptoms like pain, fatigue, & neurocognitive issues, highlighting disease complexity. PMID:42208496, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00511-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to cell fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪