Unlocking myxobacteria: New genetic tools and a heterologous chassis boost bioactive compound discovery. MxRecET recombinases enhance genome editing in Myxococcus xanthus DK1622. PMID:42373632, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74908-x #Medsky #Pharmsky #RNA #ASHG 🧪

Arabidopsis seeds pack histone variant H2B.8, arranging 3D nuclear space. Upon imbibition, H2B.8 is evicted, hinting at chromatin reprogramming in seed-to-seedling transition! PMID:42373623, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74230-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

71F with speech, gait issues, hearing loss found with infratentorial superficial siderosis & T-spinal cord cleft. Fascinating case! PMID:42371616, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.1992 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discoveries in viral replication: UL9 protein of HSV-1 forms DNA tethers and loops at oriS. A direct view into herpesvirus genome replication mechanisms. PMID:42373616, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74361-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP activates a unique 3TM-SMODS model promoting membrane shearing in anti-phage immunity, revealing novel insights into prokaryotic antiviral defenses. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

12 cave lion genomes from over 100,000 years reveal distinct lineages from modern lions, with unique variants and signs of ancient gene flow. Evolutionary secrets uncovered! PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Noninvasive neuroprosthesis breakthrough: Brain2Qwerty decodes sentences from brainwaves in 35 volunteers. High potential with no surgery needed! #Neurotech PMID:42374156, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02303-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Autoimmune encephalitis research hits a plateau in novel autoantibody discovery. Shifting focus may better aid patients. PMID:42371641, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.1659 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new model analyzes mammalian cortical connectomes, revealing that spatial constraints design unique connectivity profiles across regions in complex networks. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 3.6M+ adults in Chile shows severe COVID-19 may increase TB risk. Urgent need for monitoring post-COVID recovery! Let's discuss the implications. PMID:42373634, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74528-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

T cell activation triggers ADAM17 to cleave a 15-aa CD62L motif, enabling rapid CAR receptor shedding & reducing CAR expression with tonic signaling. Exciting progress in T cell autonomy! PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky 🧪

Study identifies >1,000 somatic variants in 311 AD brain samples, linking cancer driver genes, clonal hematopoiesis, and neuroinflammation via microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel trimodal platform integrates in vivo Ca²⁺ imaging, detailed neuron morphology, and in situ transcriptomics, linking neuronal activity to function for 30 neurons. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A comprehensive study of 470 angiosperm species reveals 132 ancient WGD events cluster non-randomly, highlighting polyploidy as a major evolutionary driver amid environmental upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA 🧪

A genetic variant, rs17437411, linked to lowered blood counts and cancer protection disrupts the lncRNA HOXA opposi, highlighting its role in regulating hematopoietic stem cells. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG 🧪

New research reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats, one of which binds human ACE2, highlighting potential zoonotic risks. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with XK in lipid transfer, highlighting its role in bridging membranes at contact sites with hydrophobic channels for efficient lipid delivery. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Study reveals "cross-language neurons" in human hippocampus, responding to similar words (e.g., "tierra" & "earth"). Key insight: semantic tuning bridges bilingualism! 🧠✨ PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals how eIF2B's allosteric disordering controls ISR by shifting eIF2's role from substrate to inhibitor under stress. PMID:42373951, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02256-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals TRPC4/5 channels key to tFUS effects in mice's retrosplenial cortex, reducing sensitivity and activating early growth response. Exciting progress! PMID:42373633, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74779-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪