T cell activation triggers ADAM17-mediated cleavage via a 15-aa motif, enabling control over CAR expression. This innovation reduces CAR levels based on tonic signaling. PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies E3 ubiquitin ligase MARCH7 as a crucial ferro-guardian against ferroptosis, regulating iron homeostasis by targeting NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway senses dsDNA, linking innate immunity and cellular responses. Key to antitumor immunity, it also drives inflammatory disorders. #Immunology #Research PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel library of 84 CRISPR-Cas9 mouse lines enables in vivo screening of host factors in influenza A research, overcoming bottlenecks in functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur is crucial for CD8⁺ T cell fate, driving 60% toward glutathione and 40% for iron-sulfur clusters, influencing proliferation and anti-tumor immunity. PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring SMVT with cryo-EM: 3 structures unveiled—occluded, outward-open, inward-open—reveal how it transports vital vitamins. Key to tackling its dysfunction! PMID:42364996, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74948-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NAD+ modulates mitochondrial vulnerability in MERTK models of retinitis pigmentosa (R… PMID:42365006, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74400-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Major breakthrough in HIV research: CRISPR screens in primary CD4+ T cells identified multiple pro- and anti-HIV host factors, revealing diverse antiviral mechanisms! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1 to sense singlet oxygen (¹O₂) and trigger photoprotection, revealing how plants manage high-light tolerance through protein condensates. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veggies reveals garlic as a potent inhibitor of mating & egg-laying in Drosophila. Diallyl disulfide shows promise in pest control! 🧄✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chronic suppression of MDR Pseudomonas aeruginosa in a prosthetic joint infection achieved via personalized bacteriophage treatment after antibiotics failed! PMID:42364990, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74326-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel LLM-assisted scoring framework identifies GPNMB as a promising CAR T target in melanoma, leukemia, and colorectal cancer, addressing a key bottleneck in therapy. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies TMEM154/Galvanin as a key receptor enabling cells to sense electric fields (≤ 100 mV/mm) and migrate toward the cathode. Exciting times! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing spermatogenesis studies, 2,653 genes in 867,062 mouse testis cells reveal dynamic cycles in Sertoli cells, aligning transcription with germ-cell differentiation. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Aging male mice show disrupted water balance/thermoregulation: AVP neurons in hypothalamus are key. RNA-seq finds Avp upregulated. Old neurons enlarged, more excitable. PMID:42364986, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74819-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA locus lowers blood counts, protects against blood cancers, and alters phenotypes, linked to a new lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive vascular integrity in small-cell lung cancer leads to immune desertification. Wang et al. propose "reverse normalization" to enhance immunotherapy efficacy. PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research shows heat stress in mice elevates KLK14, leading to metabolic dysfunction on an obesogenic diet. Heat stress affects 1 in 3 mice’s metabolic health! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host gut metabolism using its Bacteroides fragilis toxin, fostering an oxidative environment that promotes its growth amid inflammation. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪