The cGAS-STING pathway detects dsDNA, triggering immunity and responses to cell stress. It influences tissue health & antitumor effects while linking to inflammatory diseases. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG 🧪

New study maps 89,000 gene interactions in HAP1 cells using CRISPR, revealing hierarchical modules linked to protein complexes and advancing gene co-essentiality insights. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in CD4+ T cells identified key pro- and anti-HIV host factors, revealing diverse antiviral mechanisms and potential therapeutic targets. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a conserved ZnF domain protein, to sense ¹O₂ and activate photoprotective responses, showcasing a novel mechanism for light tolerance. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on bridge-like lipid transfer! Cryo-EM reveals VPS13A interacting with XK, unraveling mechanisms of vesicle-independent lipid transfer between organelles. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk over 5 years ahead, aiding prevention. CANTOS showed IL-1β inhibition can reduce incidence, but NNT remains high. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

In SOD1-G93A mice, alpha motor neurons transition into a unique "disease-associated motor neuron" state before cell death, revealing 1000s of molecular changes! PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study shows prion-based switching in DNA repair proteins boosts mutagenesis in S. cerevisiae, enhancing adaptability across diverse environments. Evolutionary game-changer! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG 🧪

New research reveals two clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats, with one clade binding human ACE2, enhancing zoonotic transmission risk. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR-Cas9 mouse library targeting 84 host factors enhances in vivo screening for influenza A, bridging in vitro data gaps and boosting viral research. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of human fertilized eggs arrest in pre-implantation due to error-prone second mitotic divisions. PLK4 inhibition reduces centriole overduplication, improving development. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New data reveals that after bivalent CAR T cell therapy for recurrent GBM, prolonged survival was linked to the endogenous immune response; detailed profiling of CSF was key! PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in Duchenne muscular dystrophy using LEAPER 2.0! Circular arRNAs enable long-term exon skipping, reversing muscle degeneration in monkeys and humans. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cellular senescence shows diverse states across tissues in aging and disease, revealing 40+ senotypes and enabling targeted therapies via AI-driven multi-omics insights. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AD brain analysis of 311 samples revealed >1,000× sSNVs in cancer driver genes, linked to clonal hematopoiesis, driving expansion in microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery of GPNMB CAR T cells reveals a novel multi-cancer therapy, refining targets with single-cell RNA seq from 1k+ human samples. Exciting progress! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying key regulators influencing cell fate shifts. A game changer in cell-state prediction! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain enhance sustained attention, challenging the role of cholinergic neurons! PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin causes neuronal death by activating nucleotide excision repair (NER), which paradoxically promotes damage instead of protecting neurons. #Neurotoxicity PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings show that allergens trigger PAR1-dependent ferritinophagy, raising intracellular iron levels, crucial for noncanonical GSDMD activation in allergic airway diseases. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA #ASHG 🧪