New findings reveal that macrometastases in breast cancer activate a Metastatic Trabecular Morphogenesis (MTM) program, leveraging developmental pathways for expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover life science tools with bio.tools: a registry offering easy access and metadata for 15K+ software solutions. ✨ Search smarter! PMID:42363751, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag420 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation & chronic pain after repeated E. coli infections, linked to IL-6. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Unlocking genome regulation: A new method analyzes over 1.6M compositions, tests 653, & finds a buffer boosting mRNA by 20x for clearer gene expression insights. PMID:42364991, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74559-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A model reveals that geometric constraints significantly shape mammalian cortical connectomes, highlighting 3D connectivity's role in their complex architecture. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals hippocampal neurons link bilingual semantics—finding "cross-language neurons" responding similarly to words like "tierra" (spanish) and "earth" (english). PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals CD8+ T cell immunity enhances tumor sensitivity to cuproptosis, suggesting a link between copper-induced cell death and improved immunotherapy outcomes. PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Prion-based protein self-assembly enables rapid adaptive mutagenesis in Saccharomyces cerevisiae populations, altering DNA repair mechanisms for evolution. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP promotes membrane shearing, enhancing phage immunity via TM proteins in the CBASS system, revealing key antiviral mechanisms. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements, making up nearly 50% of mammalian genomes, play key roles in shaping gene expression, evolution, and disease through locus-specific regulation. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New clades of SARS-CoV-2-related coronaviruses found in Thai horseshoe bats show ability to bind human ACE2; dynamic virology raises significant concerns! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel blood-brain barrier-like vascular gate in small cell lung cancer limits immune cell infiltration, explaining the poor immunotherapy response in SCLC. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a groundbreaking tool that integrates gene regulatory networks with RNA velocity, identifying 7 key regulators influencing cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study on 3,987,182 COVID-19 cases in Korea shows higher asthma risk post-infection for those with systemic atopy or upper-airway disease. Who else saw this connection? PMID:42364998, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74860-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research unveils a "disease-associated motor neuron" state in ALS, revealing 1000s of molecular shifts in SOD1-G93A model. Key insights on transcription factors emerge! PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that targeting macrophage ferritin heavy chain (FTH1) can reduce ferroptosis and lung damage in ARDS. Elevated serum ex-ferritin ties to worse outcomes. PMID:42364999, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74828-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

BsAb EVs target FAP⁺ fibroblasts in 1 surgical model, redirecting T cells to reduce epidural fibrosis effectively post-surgery. Potential game-changer for recovery! PMID:42364978, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74883-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

T cell activation triggers ADAM17-mediated cleavage via a 15-aa motif, enabling control over CAR expression. This innovation reduces CAR levels based on tonic signaling. PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies E3 ubiquitin ligase MARCH7 as a crucial ferro-guardian against ferroptosis, regulating iron homeostasis by targeting NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway senses dsDNA, linking innate immunity and cellular responses. Key to antitumor immunity, it also drives inflammatory disorders. #Immunology #Research PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪