Discover how a rapid CIU assay predicts agonism in hIgG2 mAb variants by analyzing gas-phase unfolding and hinge-engineering, revolutionizing antibody design. PMID:42373639, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75137-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Xenophagocytosis by host macrophages hinders interspecies chimerism in organ transplantation. Blocking this could boost xenogeneic cell engraftment, a major breakthrough! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale map reveals ~89,000 high-confidence gene interactions in HAP1 cells, organizing genes into hierarchical modules, crucial for targeted therapies. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals TMEM154/Galvanin acts as a cellular antenna, sensing electrical fields to guide cells' migration towards the cathode with precision. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Astronauts' plasma metabolomics (n=52) before, during, after ISS missions reveal microgravity boosts gut microbial protein fermentation, altering metabolism.🚀 PMID:42373641, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74979-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe reprogramming of human somatic cells to pluripotency, balancing genome stability with Yamanaka factors. Essential insights for safer cell fate manipulation! PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG 🧪

A groundbreaking LLM-assisted scoring framework identified GPNMB as a promising CAR T target for 3 cancers: melanoma, leukemia, and colorectal cancer. #CARtherapy PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel neural network, Deep-Phase, links cellular condensate morphology to biochemical processes, revealing how drugs induce structural changes. Fascinating insights! PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replaying 100+ monoclonal GC reactions reveals how B cell competition shapes antibody affinity evolution using deep mutational scanning, unlocking Darwinian dynamics in action. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Cysteine's sulfur partitioning impacts T cell fate: its routing fuels CD8⁺ T cell proliferation and anti-tumor immunity via glutathione and iron-sulfur synthesis! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing CANVAS: an AI platform that deciphers TME spatial architecture from H&E histopathology, built on 18M+ cells, advancing tumor ecology insights and therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Spermatogenesis is mapped in 867,062 mouse testis cells, revealing 2,653 genes showing a cycle. Sertoli cells sync transcriptionally, advancing understanding of fertility. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new model reveals that the unique topology of mammalian cortical connectomes arises from physical constraints, with 90% of connections focused in specific regions. Insightful! PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG 🧪

A study reveals that >2700 human mRNA 3' UTRs with conserved nucleotides modulate protein activity, specifically by altering JMJD3 folding via its KDM6B 3' UTR. PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

12 cave lion genomes from over 100,000 years reveal distinct evolutionary lineages from modern lions, showcasing unique variants & ancient gene flow between them. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway detects dsDNA, triggering immunity and responses to cell stress. It influences tissue health & antitumor effects while linking to inflammatory diseases. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG 🧪

New study maps 89,000 gene interactions in HAP1 cells using CRISPR, revealing hierarchical modules linked to protein complexes and advancing gene co-essentiality insights. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in CD4+ T cells identified key pro- and anti-HIV host factors, revealing diverse antiviral mechanisms and potential therapeutic targets. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a conserved ZnF domain protein, to sense ¹O₂ and activate photoprotective responses, showcasing a novel mechanism for light tolerance. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on bridge-like lipid transfer! Cryo-EM reveals VPS13A interacting with XK, unraveling mechanisms of vesicle-independent lipid transfer between organelles. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪