Engineered macrophages show promise for cancer immunotherapy, but ex vivo expansion of granulocyte-monocyte progenitors (GMPs) is challenging. This study reveals defined culture conditions for long-term… PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #RNA 🧪

A phytoscreen of 43 fruits & veggies found garlic a strong deterrent of mating & egg-laying in Drosophila. Diallyl disulfide blocked both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover PRIME: a hybrid deep learning tool to pinpoint metal-binding sites in metalloproteins with unmatched accuracy. Revolutionizing studies with complex proteins! 🔬 PMID:42380105, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74657-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 2 co-circulating clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats; one clade binds human ACE2 efficiently—possible pandemic threat. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that the neuronal gene Arc is essential for tau release in EVs. rTg4510 model EVs from Arc KO mice show 50% less tau, impairing seeding potential. PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Bora, CEP192, and Cenexin selectively regulate Plk1 processes: Bora aids mitotic entry; CEP192 in centrosome maturation; Cenexin in centriole disengagement. Science! PMID:42380115, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75033-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows specific gut metabolites worsen cognitive deficits and tau pathology in hTau.P301S mice. Antibiotics surprisingly make things worse! Neurodegenerative link? PMID:42380200, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74775-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal MBS1, a conserved protein with a zinc-finger domain, aids chloroplasts in sensing singlet oxygen (¹O₂) to enhance high-light tolerance and activate defense pathways. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA 🧪

Replaying 100+ monoclonal germinal center reactions reveals how B cell competition drives antibody affinity evolution, reshaping immunoglobulin gene dynamics. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights into Plasmodium falciparum's invasion: a sailboat-shaped 1:1:1:1 assembly of PfAMA1 and PfRONs anchors the moving junction, revealing its role in host cell remodeling. #Malaria #DrugDiscovery PMID:42379167, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00699-9 #RNA 🧪

Study of 470 angiosperms reveals 132 ancient WGD events show non-random clustering, highlighting polyploidy’s key role in evolution amid upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress increases susceptibility to metabolic dysfunction via elevated skin-derived KLK14, affecting hypothalamic LRRC7+ astrocytes in mice. Fascinating link! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, merging gene regulatory networks with RNA velocity analysis to identify 10+ potential regulators influencing cell fate transitions. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 12 cave lion genomes spanning 100k+ years show cave and modern lions were distinct lineages with separate histories and unique mutations! PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Furmonertinib 160 mg daily shows mPFS of 16.59 mo in 40 untreated EGFR-mutant NSCLC patients with CNS metastases. PMID:42379171, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00321-6?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG 🧪

LEAPER 3.0 enhances ARNA design, using AlphaFold 3 to optimize endogenous ADAR for precise RNA editing. This innovative platform boosts editing efficiency and precision, revolutionizing RNA manipulation! PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #RNA 🧪

A new LLM-assisted scoring framework has identified GPNMB as a promising CAR T cell target across 3 cancer types: melanoma, leukemia, and colorectal cancer. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Promising results in DMD treatment: LEAPER 2.0 uses circular ADAR-recruiting RNAs for effective exon skipping in monkeys & humans, reversing muscle degeneration. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS reveals tumor ecosystems via AI, leveraging 18M+ cells from H&E histopathology, enhancing understanding of TME's role in disease progression. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CD8+ T cells use cysteine for GSH production, enhancing effector functions, and for sulfur in FeS cluster synthesis via NFS1, crucial for proliferation. NFS1 deletion leads to T cell exhaustion. PMID:41923640, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00279-5 #Medsky #RNA 🧪