A 10-year study on 1,513 CRKP isolates reveals a dominant ST11-KL64 sublineage with enhanced invasiveness from genome data spanning 60,724 Klebsiella pneumoniae. PMID:42373658, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74832-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a groundbreaking framework that combines gene regulatory networks with RNA velocity, pinpointing key regulators shaping cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering high-confidence effector genes in osteoarthritis: Transcriptome analysis of 261 low-grade and diseased tissues from knee osteoarthritis patients reveals crucial insights! PMID:42373672, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74993-y #Medsky #Pharmsky #RNA 🧪

Groundbreaking study reveals a co-culture system of ESCs with extra-embryonic cells, mimicking primitive streak formation—a key to understanding human gastrulation! PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 revolutionizes RNA editing by harnessing endogenous ADAR with engineered arRNAs, paving the way for precise edits via AlphaFold 3 structure insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mendelian randomization reveals causal ties between risk factors & disease progression. Index event bias impacts analyses significantly. #Epidemiology PMID:42372731, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00230-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

⭐New PBM on the Rocks is live!

UnitedHealthcare's AI called a pharmacy to refill a script for a dead patient & PBMs call themselves #healthcare's most transparent industry.

Joe Shields of Transparency Rising on corporate's new trick: Transparency Washing
youtu.be/SvKaDUYoQr4

#podcast #PharmSky

ETBF rewires host metabolism using Bacteroides fragilis toxin to thrive in the inflamed gut, fueling oxidative growth and contributing to colitis and colorectal cancer. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements (TEs) make up nearly 50% of mammalian genomes, influencing gene expression and disease through their DNA and RNA forms, despite mostly losing mobility. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

E. coli's DnaB helicase, key in DNA replication, efficiently unwinds DNA when correctly loaded, challenging the old view of limited ATP-motor coupling efficiency. PMID:42373613, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73652-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover key findings: Unique fibrotic pericyte cluster identified in pulmonary fibrosis using single-cell RNA-seq in human lungs and mouse models, unlocking DNA regulation insights. PMID:42373667, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74910-3 #Medsky #Pharmsky #RNA 🧪

Neonatal MR1T cells show diverse TCRs but only 30% have bacterial recognition compared to adults (70%). Significant insight into sepsis protection. Discuss! PMID:42373629, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74998-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals enzyme clustering enhances CoQ biosynthesis via substrate channeling. Molecular dynamics and biochemical tests show COQ metabolons form at phase transitions. PMID:42373663, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74806-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Disrupting Ip6k2-Runx2 stops osteoblasts and osteoclasts from coupling, offering new osteoporosis treatment. Dual role discovery could change OP management. PMID:42373645, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75098-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cryo-EM structure of HIV-2 Vif with human APOBEC3H and CBFβ shows how Vif bypasses retrovirus immunity. A3H forms 2-part dimer linked by dsRNA, revealing key viral tactics. PMID:42373647, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75045-1 #Medsky #Pharmsky #RNA #ASHG 🧪

D-SPIN constructs gene regulatory network models from single-cell RNA-seq, revealing how cells modulate gene expression to maintain homeostasis and respond to perturbations. PMID:42127893, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation and chronic pain during uropathogenic E. coli infection through IL-6 signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG 🧪

Study shows promising results: Neoadjuvant fulvestrant + abemaciclib achieves high clinical benefit rate in advanced low-grade serous ovarian carcinoma. Insightful findings! PMID:42374029, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74571-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery of GPNMB CAR T cells could transform multi-cancer therapy, optimizing target identification from 1000s of single-cell RNA sequences. Exciting potential! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

PBM execs swore under oath they pass through 100% of rebates.
The next day, CVS settled for $43M.

That's transparency washing. Joe Shields of Transparency Rising scrubs it clean on a new PBM on the Rocks.

Episode Drops Tomorrow! ⏰
#PBMreform #IndependentPharmacy #PBMOTR #PharmSky