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@plosbiology.orgOct 6, 2026, 8:15 AM

Why do some neurons die in #neurodegeneration while closely related neighbors survive? This Essay by Dong Won Kim argues that disease resistance may depend on maintenance of a neuron's #cell identity and proposes tests of the model.
🧪 #AcademicSky
plos.io/4y7cGbA

Reversible cell-state remodeling vs. identity-maintenance failure in adult neurons.
An adult neuron with stable subtype identity (left) depends on continued operation of four interrelated regulatory components, shown in the inset legend: (1) identity transcription factors; (2) accessible identity enhancers; (3) coherent terminal effector gene modules; and (4) active repression of alternative gene programs belonging to other cell types. Under stress (metabolic, proteostatic, inflammatory, or pathological), the neuron can follow one of two trajectories. (A) In reversible cell-state remodeling, the neuron mounts adaptive responses such as the heat-shock response and the unfolded protein response (UPR), while identity transcription factor activity, enhancer accessibility, terminal effector modules, and repression of alternative programs remain intact. When the stress is removed, the neuron returns to its prior identity state. (B) In identity-maintenance failure, similar stress responses occur, but the regulatory machinery that stabilizes subtype identity itself weakens: identity transcription factor activity falls, identity enhancers lose accessibility, terminal effector modules decohere, and repression of alternative or neighboring-cell programs (orange) fails, allowing those programs to be expressed. After sustained disruption of this machinery, return to the prior identity state may be incomplete, delayed, or unstable even after the initiating stress is removed (broken recovery arrow), and degeneration may follow. The stress-response components are shown at comparable intensity in both panels to emphasize that the framework concerns identity-regulatory outcomes under matched stress exposure, not differences in stress response itself. Neuron illustration adapted from NIH BioArt Source, “Healthy neuron” (BIOART-000197), Public Domain, Courtesy of NIAID.
@prepub-neurodegen.bsky.socialOct 6, 2026, 7:03 AM

GLACIER: Rethinking Mass Spectrum Prediction as an Object Detection Problem #NeuroDegeneration 🧪🧠
https://arxiv.org/abs/2606.29161

@prepub-neurodegen.bsky.socialOct 6, 2026, 7:03 AM

A multimodal computer-vision based pipeline for eye-hand coordination quantification during the Nine-Hole Peg Test #NeuroDegeneration 🧪🧠
https://arxiv.org/abs/2610.05553

@prepub-neurodegen.bsky.socialOct 6, 2026, 7:03 AM

Beyond Completion Time: A Multimodal Approach to Characterizing Eye-Hand Coordination During the Nine-Hole Peg Test in Multiple Sclerosis #NeuroDegeneration 🧪🧠
https://arxiv.org/abs/2610.04145

@prepub-neurodegen.bsky.socialOct 6, 2026, 4:01 AM

Neurons in the lateral spinal nucleus give rise to the spinotectal component of the anterolateral system in the mouse #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.29.755366v1

@prepub-neurodegen.bsky.socialOct 6, 2026, 1:02 AM

DIAGNOSTIC ACCURACY IN SELECTIVE CARIES REMOVAL: An In Vitro Comparison Between DIAGNOcam Vision Full HD Fluorescence Imaging and Caries Detector Dyes Using Histological Validation #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11132129/latest

@prepub-neurodegen.bsky.socialOct 6, 2026, 1:02 AM

Multi-scale electrophysiological characterization of human cardioids reveals progressive maturation #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.29.755336v1

@prepub-neurodegen.bsky.socialOct 6, 2026, 1:02 AM

Explainable machine learning identifies predictors for postural instability and cognitive impairment in early Parkinsons Disease #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.09.30.26364120v1

@prepub-neurodegen.bsky.socialOct 6, 2026, 1:02 AM

Sample Size and Power Calculations Based on Endpoint Responsiveness: Applications to Trials of Disease-Modifying Therapies in Parkinson's Disease #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.09.29.26363876v1

@prepub-neurodegen.bsky.socialOct 6, 2026, 1:01 AM

Hyperexcitable primary somatosensory cortex in the MitoPark mouse model of Parkinson's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.29.755142v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:03 PM

The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.29.754953v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:03 PM

Polyglutamine aggregation proceeds by stochastic nucleation in the C. elegans nervous system #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.29.755284v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:02 PM

Magnetic Field Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimers Disease an In Silico Study #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.28.755051v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:02 PM

Imputation-Based Harmonization Mitigates Site Effects Without Data Leakage in Machine Learning Studies #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.28.755204v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:02 PM

Plasma eMTBR-tau as a robust biomarker for Alzheimer's disease tangle pathology up to 10 years before death #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.09.29.26363951v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:02 PM

Volumetric Integrity of Frontotemporal and Perisylvian Regions for Predicting Behavioral and Language Impairment in Behavioral FTD: A Structural MRI Study #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.09.30.26364390v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 10:01 PM

Speed-emphasized arm training is consistent with improved feedforward control of rapid elbow flexion in chronic stroke #NeuroDegeneration 🧪🧠
https://www.medrxiv.org/content/10.64898/2026.10.02.26364609v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 7:03 PM

Templated seeding induces the formation of Alzheimer paired helical tau filaments in human brain organoids #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755295v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 7:02 PM

Templated paired helical filament formation and tau fold-dependent inclusion morphologies in primary neurons #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755038v1

@prepub-neurodegen.bsky.socialOct 5, 2026, 7:02 PM

Restoration of (nor)adrenergic-like Ca2+ signalling counteracts age-related motor decline #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.28.754926v1

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