Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying key regulators influencing cell fate shifts. A game changer in cell-state prediction! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain enhance sustained attention, challenging the role of cholinergic neurons! PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin causes neuronal death by activating nucleotide excision repair (NER), which paradoxically promotes damage instead of protecting neurons. #Neurotoxicity PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study on NSCs reveals that MAP1B, a microtubule-associated protein, shuttles to the nucleus, linking cytoskeletal dynamics to transcriptional regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered GMPs enable long-term expansion of mouse and human progenitors for tumor immunotherapy, powered by myeloperoxidase's role in proliferation. Transformative! PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel pooled imaging method, VIS-seq, analyzed ~3,000 LMNA & PTEN variants, uncovering high-dimensional phenotypic profiles linked to protein behavior and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism via its virulence factor to thrive in the inflamed gut, fueling oxidative growth in the large intestine and linking to colitis & CRC. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cells can detect and navigate electrical fields via the receptor TMEM154/Galvanin, guiding movement toward the cathode. A breakthrough in cell migration studies! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RegVelo merges gene regulatory dynamics with RNA velocity, enabling deeper insights into cell fate transitions by modeling splicing kinetics and GRN interactions. PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits identified garlic as a strong mating & egg-laying deterrent in Drosophila, with diallyl disulfide inhibiting these behaviors. Fascinating! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on polyploidy reveal 132 ancient whole-genome duplications across 470 angiosperm species, showcasing non-random clustering during environmental upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New trimodal platform combines in vivo Ca²+ imaging, single-neuron morphology, and transcriptomics, enabling comprehensive insights into neuronal functions! PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting progress in DMD treatment: long-term reversal achieved via circ-arRNA-guided exon skipping in monkeys and humans, leveraging ADAR for effective RNA editing! #DMD PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe human somatic cell reprogramming toward pluripotency, balancing genome stability with Yamanaka factors for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 1,025 species reveals that early unicellular genomes were random; evolution led to structured "global folding" & "checkerboard" formations in complex life. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, suggesting a possible single-sex population. Fascinating! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Single-cell mapping of DNA-protein interactions via D&D-seq reveals insights into transient TF bindings, enhancing understanding of gene regulation at single-cell resolution. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new non-invasive genetic system reveals that brain protein clearance follows unique routes to CSF, uncovering drainage hotspots often missed by traditional tracers. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel experimental model reenacted 100+ monoclonal germinal center (GC) reactions, revealing insights into B cell competition and affinity maturation dynamics. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal that macrometastases in breast cancer activate a Metastatic Trabecular Morphogenesis (MTM) program, leveraging developmental pathways for expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪