The recording of the latest Molecular Presents webinar, AI-Powered Precision Medicine: From Biomarker Discovery to Therapeutic Design and Delivery, is now available!

Watch it here today: http://dlvr.it/TVmhly

#AI #MachineLearning #RNA #ASGCT

A study reveals that 3D morphogenetic processes drive metastatic outgrowth in breast cancer. Macrometastases activate a specific gene-expression program, transforming development pathways into lethal growth. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #RNA 🧪

Via Euronews: Gene therapy: The breakthrough that inspired Spider-Man | Euronews Tech Talks
www.euronews.com/2026/09/30/g...
#RNATherapy #RNA #GeneTherapy #SpiderMan #HowDoesItWork

Single-cell D&D-seq reveals precise DNA-protein interactions, unlocking insights into gene regulation by TFs. This tool transforms understanding of chromatin dynamics. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF reprograms host metabolism via B. fragilis toxin to thrive in the inflamed gut, revealing insights into pathogen-host dynamics. Key findings show its role in nutrient niche establishment crucial for… PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #RNA 🧪

A genetic variant (rs17437411) linked to lower blood counts and reduced blood cancer risk disrupts an unstudied lncRNA (HOXA) between HOXA7 and HOXA9, revealing key insights into hematopoiesis. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #RNA 🧪

Nuclear and cytosolic proteomics of NSCs reveal abundant cytoskeletal proteins like MAP1B, which shuttle to the nucleus, linking microtubule dynamics to cellular fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A new model reveals how physical constraints shape the intricate topology of mammalian cortical connectomes, highlighting unique regional connectivity profiles. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway detects dsDNA, linking innate immunity to stress responses, influencing 5 key areas: antiviral defense, tissue homeostasis, antitumor immunity, and inflammatory disorders. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #RNA 🧪

Over 2,700 human mRNA 3' UTRs harbor conserved nucleotides, influencing proteins with long intrinsically disordered regions (IDRs). Key findings reveal that KDM6B's 3' UTR co-translationally alters JMJD3… PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #RNA 🧪

New study uncovers xenophagocytosis, where host macrophages eliminate xenogeneic donor cells in organ transplantation. Blocking this process increases interspecies chimerism! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A breakthrough study maps 1,000+ senescent cell types across human tissues, revealing unique programs and interactions, paving the way for targeted therapies and biomarker discovery in aging and disease! PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #RNA 🧪

New findings reveal that environmental allergens boost intracellular iron via PAR1-dependent ferritinophagy, activating GSDMD and triggering inflammatory IL-33 release in airway cells. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA 🧪

Study reveals FET proteins and PARylation aid DNA repair. Upon PARG inhibition, replication fork reversal occurs. Key in cancer therapy. Insights into genome stability! PMID:42380136, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74950-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. reveal how excessive vascular integrity in small-cell lung cancer leads to immune desertification, suggesting “reverse normalization” to enhance anti-tumor immunity and tackle immunotherapy… PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #RNA 🧪

2'3'-cGAMP triggers membrane shearing via 3TM proteins in the CBASS antiviral system, revealing key mechanisms in prokaryotic immunity against phages. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Studying neo-polyploid Arabidopsis kamchatica: detailed genomes of progenitors A. halleri & A. lyrata reveal immediate DNA methylation & gene expression shifts post-polyploidization. PMID:42380194, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75042-4 #Medsky #Pharmsky #RNA 🧪

Engineered macrophages show promise for cancer immunotherapy, but ex vivo expansion of granulocyte-monocyte progenitors (GMPs) is challenging. This study reveals defined culture conditions for long-term… PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #RNA 🧪

A phytoscreen of 43 fruits & veggies found garlic a strong deterrent of mating & egg-laying in Drosophila. Diallyl disulfide blocked both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover PRIME: a hybrid deep learning tool to pinpoint metal-binding sites in metalloproteins with unmatched accuracy. Revolutionizing studies with complex proteins! 🔬 PMID:42380105, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74657-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪