Discover PRIME: a hybrid deep learning tool to pinpoint metal-binding sites in metalloproteins with unmatched accuracy. Revolutionizing studies with complex proteins! 🔬 PMID:42380105, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74657-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 2 co-circulating clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats; one clade binds human ACE2 efficiently—possible pandemic threat. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that the neuronal gene Arc is essential for tau release in EVs. rTg4510 model EVs from Arc KO mice show 50% less tau, impairing seeding potential. PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Bora, CEP192, and Cenexin selectively regulate Plk1 processes: Bora aids mitotic entry; CEP192 in centrosome maturation; Cenexin in centriole disengagement. Science! PMID:42380115, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75033-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows specific gut metabolites worsen cognitive deficits and tau pathology in hTau.P301S mice. Antibiotics surprisingly make things worse! Neurodegenerative link? PMID:42380200, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74775-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal MBS1, a conserved protein with a zinc-finger domain, aids chloroplasts in sensing singlet oxygen (¹O₂) to enhance high-light tolerance and activate defense pathways. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA 🧪

Replaying 100+ monoclonal germinal center reactions reveals how B cell competition drives antibody affinity evolution, reshaping immunoglobulin gene dynamics. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 470 angiosperms reveals 132 ancient WGD events show non-random clustering, highlighting polyploidy’s key role in evolution amid upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress increases susceptibility to metabolic dysfunction via elevated skin-derived KLK14, affecting hypothalamic LRRC7+ astrocytes in mice. Fascinating link! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, merging gene regulatory networks with RNA velocity analysis to identify 10+ potential regulators influencing cell fate transitions. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 12 cave lion genomes spanning 100k+ years show cave and modern lions were distinct lineages with separate histories and unique mutations! PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Furmonertinib 160 mg daily shows mPFS of 16.59 mo in 40 untreated EGFR-mutant NSCLC patients with CNS metastases. PMID:42379171, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00321-6?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG 🧪

A new LLM-assisted scoring framework has identified GPNMB as a promising CAR T cell target across 3 cancer types: melanoma, leukemia, and colorectal cancer. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Promising results in DMD treatment: LEAPER 2.0 uses circular ADAR-recruiting RNAs for effective exon skipping in monkeys & humans, reversing muscle degeneration. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS reveals tumor ecosystems via AI, leveraging 18M+ cells from H&E histopathology, enhancing understanding of TME's role in disease progression. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Histone H2A variants shape epigenomic patterns in Arabidopsis through antagonistic effects, forming heterochromatin without relying on RdDM by establishing H3K9me and non-CpG methylation. PMID:42380212, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74770-x #Medsky #Pharmsky #RNA 🧪

A study reveals a blood-brain barrier-like vascular gate (BVG) in small cell lung cancer (SCLC) that restricts immune cell infiltration, explaining low immunotherapy efficacy. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG 🧪

A 10-year study on 1,513 CRKP isolates reveals a dominant ST11-KL64 sublineage with enhanced invasiveness from genome data spanning 60,724 Klebsiella pneumoniae. PMID:42373658, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74832-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a groundbreaking framework that combines gene regulatory networks with RNA velocity, pinpointing key regulators shaping cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering high-confidence effector genes in osteoarthritis: Transcriptome analysis of 261 low-grade and diseased tissues from knee osteoarthritis patients reveals crucial insights! PMID:42373672, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74993-y #Medsky #Pharmsky #RNA 🧪