IGF2BP1 regulates chicken skeletal muscle development through an m6A-dependent inter-organ regulatory axis

Poultry science · Wanying et al.
doi.org/10.1016/j.psj.2026.107856
#RNAsky #RNAmods

Pseudouridylation landscape across 42 nuclear-encoded S. cerevisiae tRNAs

bioRxiv · Barry et al.
doi.org/10.64898/2026.04.28.721490
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IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway

Journal of immunotherapy (Hagerstown, Md. : 1997) · Chen et al.
doi.org/10.1097/cji.0000000000000613
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Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing

MicrobiologyOpen · Pitt et al.
doi.org/10.1002/mbo3.70413
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Polyphenism Through RNA Chemical Modifications

Molecular ecology · Schneider et al.
doi.org/10.1111/mec.70553
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METTL1-Enhanced SMC4 mRNA Stability via m7G Modification Promotes Hepatocellular Carcinoma Progression and Confers the 5-Fluorouracil Resistance

The Tohoku journal of experimental medicine · Dan et al.
doi.org/10.1620/tjem.2026.j107
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METTL3 Increases Temozolomide Resistance in MGMT-Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A-IGF2BP2-Dependent Manner

CNS neuroscience & therapeutics · Deng et al.
doi.org/10.1002/cns.71164
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RNA modifications and metabolism in cancer: mechanisms, cross-talk and therapeutic implications

Seminars in cancer biology · Luo et al.
doi.org/10.1016/j.semcancer.2026.102622
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ACTB promotes ESCC progression by regulating the AKT-mTOR signaling pathway through an m6A-dependent mechanism

Oncogene · Jiang et al.
doi.org/10.1038/s41388-026-03995-3
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NAT10 governs development through the Xrp1-mediated stress response rather than its RNA acetylation activity

Science advances · Wang et al.
doi.org/10.1126/sciadv.aeg0399
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#RNAsky 🎉!

#RNAsky 🎉🤩!!!

Corrigendum to "PCIF1-mediated m6Am modification activates USP5/BRD4 Axis to promote glycolysis-driven immunosuppression in multiple myeloma" [Int. Immunopharmacol. 186 (2026), 117062]

International immunopharmacology · Long et al.
doi.org/10.1016/j.intimp.2026.117449
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YT521-B-mediated RNA m6A modification was involved in O3-induced male-biased sex ratio in Drosophila melanogaster

Ecotoxicology and environmental safety · Nan et al.
doi.org/10.1016/j.ecoenv.2026.120836
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Testicular m6A-RNA hypomethylation in a high-fat, AGE-rich dietary mouse model of male reproductive dysfunction

Reproductive toxicology (Elmsford, N.Y.) · Rajaipoor et al.
doi.org/10.1016/j.reprotox.2026.109367
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C21 ameliorates microglial ferroptosis and neuronal apoptosis after ischemic brain injury by activating the METTL3/USP18/FASN axis

Experimental neurology · Wu et al.
doi.org/10.1016/j.expneurol.2026.116036
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RNA m6A demethylase FTO in central nervous system disorders: Mechanisms and therapeutic implications

Progress in neuro-psychopharmacology & biological psychiatry · Bi et al.
doi.org/10.1016/j.pnpbp.2026.111942
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Dear fellow #microbiologists, I am currently in a debate over whether or not it is required to validate differential gene expression findings from RNAseq by qPCR. People have very strong opinions about this, and whether it’s required for publication.

Care to weigh in?

#RNAsky #academiasky

Phosphorothioates protect therapeutic ASOs and siRNAs from nucleases. It turns out archaea make them naturally, with a single stereochemistry and dedicated writer enzymes. New in Cell from Maman et al.

Read the paper linked in the comments below.

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