Cisplatin triggers neuronal death via NER, which paradoxically harms neurons unlike in dividing cells, highlighting the need for better neuroprotective strategies. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism via its virulence factor, Bacteroides fragilis toxin, fueling oxidative growth in the inflamed gut, critical for disease progression. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights into lipid transfer reveal that VPS13A, a bridge-like lipid-transfer protein, forms a complex with the scramblase XK, facilitating organelle communication. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive sensory response via PIEZO1 in bladder epithelial cells can drive chronic pain from uropathogenic E. coli infection, revealing a critical link with IL-6 signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal that parvalbumin-expressing neurons in the basal forebrain enhance sustained attention by disinhibiting cortical pathways, challenging prior beliefs about cholinergic neurons. PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky 🧪

Explore variability among 218 metabolic enzymes across single cells using imaging-based proteomics—uncover non-genetic diversity impacting drug resistance and immune response. 🚀 PMID:42393051, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74172-z #Medsky #Pharmsky #RNA #ASHG 🧪

VPS13C/PARK23, a lipid transport protein, is crucial for lysosome repair. It binds lysosomes under stress, triggering repair via major membrane alterations. PMID:42393076, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75145-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A model reveals the mammalian cortical connectome's intricate topology, shaped by physical constraints and unique regional connectivity profiles. Fascinating insights! PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore a vast 14M cell dataset from 47 tissues, revealing 379 hormone/receptor interactions. Discover novel hormone sites! PMID:42207862, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeb2672 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ILC2s crucially regulate fibroblast balance in the pancreas, localizing with Pi16⁺Dpp4⁺Ly6c⁺ fibroblasts in the exocrine niche. Fascinating! PMID:42391385, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aea5113 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A critical density regime aids in integrating cell heterogeneity with tissue and chromatin, stabilizing intestinal patterning during regeneration (1-6). PMID:42379166, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00696-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RNF2, a key part of polycomb repressive complex 1, boosts H2A ubiquitination, hindering monocyte-macrophage transition and worsening colitis in mice. PMID:42386751, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74962-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, hinting at a single-sex sample and unique traits. PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Galvanin (TMEM154) acts as a sensor for electric fields, crucial for immune and epithelial cells to migrate toward wounds, aiding injury response. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in primary CD4+ T cells identified numerous pro- and anti-HIV host factors, uncovering new antiviral mechanisms with high-confidence hits. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new trimodal platform enables simultaneous in vivo Ca²⁺ imaging, morphological reconstruction, and transcriptomic profiling of single neurons, advancing understanding of neuronal function. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky 🧪

Novel therapy: GPNMB CAR-T cells tackle glioblastoma by dual targeting tumor and myeloid cells, overcoming macrophage-driven growth and heterogeneity issues. 🔬💡 PMID:42386964, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10641-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

9p21.3 is vital for CAD risk, significant in EU, EA, SA, ME but absent in African cohorts. Allelic diversity matters! #HeartHealth PMID:42385718, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00233-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Multiple sclerosis: a chronic autoimmune CNS disorder. 500k+ deal with it yearly. Attacks myelin, causes neurodegeneration & disability. PMID:42384871, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMra2501195 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Recurrent patterns of TOP1-mediated genomic damage in 469 neurons reveal increased somatic mutations in ALS, FTD, and AD, highlighting shared neurodegenerative mechanisms. PMID:42385702, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00700-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪