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@phagepasteur.bsky.socialSep 18, 2026, 7:47 AM

2026 seemed to be the summer of #phage in the press 🎥 and we've been happy to participate

This is a good way to get the message out there about phage #therapy and we're definitely noticing increased interest

The Boss is scheduled for a couple more of these interviews. We'll keep you posted 😎

@phagepasteur.bsky.socialSep 17, 2026, 8:56 PM

We'll be participating in this online course from @pasteuredu.bsky.social and so should you!!

Enrollment is now open and the format provides several advantages in terms of language and timing

Take a look at the program and join us to learn more about how #phage can be used against #AMR

@plosbiology.orgSep 17, 2026, 4:25 PM

Most #bacterial immune systems raise an alarm when they sense a #phage. This Primer explores a @plosbiology.org study showing how type II Panoptes reverses this logic by maintaining a quiet signal & sensing infection through its sudden disappearance 🧪 Paper: buff.ly/1ixwg9v Primer: buff.ly/WmnHZBp

Type II Panoptes inverts the logic of nucleotide signaling in bacterial immunity. Top: In type III CRISPR-Cas, Cas10 synthesizes cyclic oligoadenylates (cAn) only upon infection; the signal binds and activates a CARF effector, arresting growth. Type II Panoptes does the reverse. Its mCpol enzyme produces cA3 constitutively at low levels, and this signal keeps the CARF-TM effector repressed. Infection is sensed not as the appearance of a signal, but as its disappearance: when phage enzymes (Acb1 given as an example) deplete cA3, the effector is released and growth arrests. Bottom: Because Acb1 evolved to disable cyclic-nucleotide defenses such as type III CRISPR, a phage carrying it strips cA3 as collateral damage and triggers Panoptes. A phage lacking Acb1 avoids this trap but remains vulnerable to CRISPR. Together, the two systems could impose an evolutionary trade-off on the phage.
@plosbiology.orgSep 17, 2026, 8:05 AM

Most #bacterial #immune systems raise an alarm when they sense a #phage. This Primer explores a @plosbiology.org study showing how type II Panoptes reverses this logic by maintaining a quiet signal & sensing infection through its sudden disappearance 🧪 Paper: buff.ly/1ixwg9v Primer: buff.ly/WmnHZBp

Type II Panoptes inverts the logic of nucleotide signaling in bacterial immunity. Top: In type III CRISPR-Cas, Cas10 synthesizes cyclic oligoadenylates (cAn) only upon infection; the signal binds and activates a CARF effector, arresting growth. Type II Panoptes does the reverse. Its mCpol enzyme produces cA3 constitutively at low levels, and this signal keeps the CARF-TM effector repressed. Infection is sensed not as the appearance of a signal, but as its disappearance: when phage enzymes (Acb1 given as an example) deplete cA3, the effector is released and growth arrests. Bottom: Because Acb1 evolved to disable cyclic-nucleotide defenses such as type III CRISPR, a phage carrying it strips cA3 as collateral damage and triggers Panoptes. A phage lacking Acb1 avoids this trap but remains vulnerable to CRISPR. Together, the two systems could impose an evolutionary trade-off on the phage.
C@celineszogesschwar.bsky.socialSep 16, 2026, 1:29 PM

Tiny Titans, your Trojan Horse, Microsin J25, a lasso peptide, bacteriocin is betrayed by Sylvie Rebuffat. #Microcins #phage #bacteria #Bacteriocins #Microbiology#Peptide #Antibiotic #AMR #Superbugs #Therapeutics #Infection #Diseases #health #Enterobacteria #Probiotics #Science youtu.be/rCovNno7MzM

@friendlymicrobe.bsky.socialSep 16, 2026, 11:33 AM

“The #phage space is developing very rapidly in the UK, and it’s an exciting time to be a part of it.” #MicroSky

C@celineszogesschwar.bsky.socialSep 16, 2026, 10:18 AM

A nightmare waiting to happen! Diseases caused by prophage encoded virulence factors: #stem #microbiology #diphtheria #botulism #Staphylococcus #diarrhea #shock #TSS #Streptococcus #Pasteurella #cholera #Shigella #Ecoli #Pseudomonas #phage #bacteria #science #disease #hospital
youtu.be/DM0H8ewv6C8

@vkleinsousa.bsky.socialSep 16, 2026, 7:22 AM

I'm happy to share one of my favorite projects from the past 4 years. 'Piercing mechanism in the minimal contractile tail of bacteriophage P2'. In this preprint, we applied #cryo-EM, #cryo-ET, TEM, and #computationalbiology to study the #phage P2 virion structure and its contraction mechanism.

@jennyrohn.bsky.socialSep 15, 2026, 6:07 PM

Our latest paper has been featured in Nature Comms' Editors’ Highlights page for Microbiology and Infection Diseases!

Do check out the paper if you're interested in #UTI, #phage, #UPEC, advanced infection #models & treatment failure!

#UTISky #MicroSky #IDSky

www.nature.com/articles/s41...

Screenshot of this webpage - who knows how long our paper will last on it ;-) https://www.nature.com/collections/jedgcgeija
@phagepasteur.bsky.socialSep 15, 2026, 1:34 PM

New lab member at the BBH!! 🚨

Niamh Diver-Hall from the @uofgsii.bsky.social is joining our #gut team for the next year, as part of her Master's degree

Her work will center in #phage defense and antidefense systems in gut bacteria 🦠

Welcome!!

@proteinimaging.bsky.socialSep 12, 2026, 10:28 AM

Here you can see a cryoEM structure of the PhiC31 integrative synapse in its CC dimer subregion (PDB code: 9IFC)

Rendering by Francisco J. Enguita made with #ProteinImager

#SciArt #molecularart #dna #insertion #synapse #phage #cryoem #integrase

@tomboylesid.bsky.socialSep 10, 2026, 10:34 AM

#phagesky #phage
I'd like to connect with anyone who can advise on how I might set up a Phage laboratory in Johannesburg, South Africa

@emmseveri.bsky.socialSep 10, 2026, 9:30 AM

#phagesky #microsky #phage

www.biorxiv.org/content/10.6...

@phagepasteur.bsky.socialSep 9, 2026, 7:01 AM

The Boss was invited to participate in the #ERSCongress2026 🫁 congress this week in Barcelona

He got to advocate for #phage therapy in front of a pretty sizeable crowd during the "Beyond antibiotics" session

Thanks for the invite!! @europeanrespsoc.bsky.social

@gltch.ioSep 8, 2026, 1:42 AM

AI just designed 16 novel, viable viruses—a first! Stanford team aims to weaponize these against antibiotic-resistant bacteria, potentially fighting superbugs. 🦠 #phage therapy

Source: https://phys.org/news/2026-08-sixteen-ai-viruses-route-drug.html

@junyazhang.bsky.socialSep 8, 2026, 1:26 AM

(4/4)A massive thanks to all my co-authors, collaborators, and ES&T for a rigorous review process. Let's keep working towards safer organic waste recycling and a healthier planet! 🌍💧 #AMR #Microbiome #Phage #OneHealth #Composting