Zonated cholesterol sensing by SIRT2 drives MASLD-HCC

#MASLD #LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.08.015

Conference on #Liver Disease in #Africa is opening in Addis Ababa, #Ethiopia this morning. Liver #cancer & #metabolic liver disease being headlined as #PublicHealth & economic threats to the continent, overlapping with endemic viral #hepatitis B.
#COLDA #diabetes #MASLD #HBV #MedSky #LiverSky 🇪🇹🧪

In a phase 2a study, THR-β agonist #ALG-055009 reduced liver fat in patients with #MASH. Study lead Dr. Loomba commented that these results support further studies evaluating “longer durations of ALG-055009 and its effect on liver histology.” #LiverSky

www.docwirenews.com/post/investi...

Immune metabolic reprogramming in MASLD

#MASLD #LiverSky #Hepatology
https://doi.org/https://www.sciencedirect.com/science/article/pii/S2589555926002983?dgcid=rss_sd_all

While vascular control of organ function mechanisms have been discovered in essentially all major organs, the mechanisms of translating milieu factors into angiocrine signalling mechanisms remain largely elusive.

#LiverResearch #LiverSky #Hepatology
https://doi.org/10.1038/s41467-026-76966-7

There's still time to register!
#liverpath #liversky #pathsky

Hepatic stellate cells (HSCs) represent an important source of cancer-associated fibroblasts (CAFs) in HCC.

#LiverFibrosis #LiverSky #Hepatology
https://doi.org/10.3389/fimmu.2026.1930718

UBE2N deficiency contributes to MASH development via p62-regulated mitophagy and PANoptosis

#MASH #LiverSky #Hepatology
https://doi.org/10.1038/s42255-026-01590-0

Restoring β-hydroxybutyrate reverses T cell exhaustion and improves antitumor, antiviral, and CAR T cell immunity in aged hosts, revealing a metabolic strategy to rejuvenate immune function during aging.

#LiverResearch #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.08.009

Molecular mechanisms and pathogenesis of MASH

#MASH #LiverSky #Hepatology
https://doi.org/10.1038/s41586-026-10529-0

Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis

#LiverResearch #LiverSky #Hepatology
https://doi.org/https://www.sciencedirect.com/science/article/pii/S0168827826002059?dgcid=rss_sd_all

The Oct 2026 issue of @LancetGastroHep is out today! www.thelancet.com/gastrohep

Content includes: #colorectalcancer, #MASLD, #viralhepatitis, #DGBI, #LynchSyndrome, bowel #endometriosis + more!

#GastroSky #LiverSky #MedSky #OncSky