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@logidias.bsky.socialOct 17, 2026, 8:10 AM

Searching 10^60 molecules is like finding one grain of sand in a billion observable universes. Quantum-targeted physics! #Science #SciSky #Physics 🔭

BBIO Integration@bio-integration.orgOct 17, 2026, 7:53 AM

Large-Scale Chemical Space Exploration Identifies DE19725241 as a Candidate Fat Mass and Obesity-Associated Protein-Targeting Compound with Selective Activity in Pancreatic Cancer Cells. Click the link below to read this #open_access article. www.scienceopen.com/hosted-docum...

scienceopen.comLarge-Scale Chemical Space Exploration Identifies DE19725241 as a Candidate Fat Mass and Obesity-Associated Protein-Targeting Compound with Selective Activity in Pancreatic Cancer Cells<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"><a class="named-anchor" id="d18403095e182"><!-- named anchor --></a><h5 class="section-title" id="d18403095e183">Background:</h5><p dir="auto" id="d18403095e185">Fat mass and obesity-associated protein (FTO), an epitranscriptomic regulator, has been implicated in cancer progression and immune regulation but the therapeutic relevance in pancreatic cancer is unclear.</p></div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"><a class="named-anchor" id="d18403095e187"><!-- named anchor --></a><h5 class="section-title" id="d18403095e188">Methods:</h5><p dir="auto" id="d18403095e190">TCGA and GTEx transcriptomic datasets were analyzed to evaluate FTO expression and prognostic associations in pancreatic cancer. Candidate FTO-targeting compounds were identified by active learning-assisted virtual screening of > 22 million compounds. The lead candidate, DE19725241, was further assessed by binding pose metadynamics, molecular dynamics simulations in multiple environments, MM/GBSA calculations, and <i>in vitro</i> testing in three pancreatic cancer cell lines and one normal pancreatic epithelial cell line.</p></div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"><a class="named-anchor" id="d18403095e195"><!-- named anchor --></a><h5 class="section-title" id="d18403095e196">Results:</h5><p dir="auto" id="d18403095e198">FTO was overexpressed in pancreatic tumors and associated with poorer overall survival. DE19725241 showed favorable predicted interactions with FTO, particularly with ARG-96, TYR-108, and GLU-234, and exhibited moderate but selective antiproliferative activity in pancreatic cancer cells.</p></div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"><a class="named-anchor" id="d18403095e200"><!-- named anchor --></a><h5 class="section-title" id="d18403095e201">Conclusions:</h5><p dir="auto" id="d18403095e203">DE19725241 represents a potential early-stage scaffold for developing FTO-targeted strategies in pancreatic cancer.</p></div>
@logidias.bsky.socialOct 17, 2026, 8:09 AM

🔭 Daily arXiv Radar | Scientific Frontier

Can quantum memory survive the chaotic storm of local noise? New insights reveal the hidden stability laws of quantum LDPC states!

📄 "Stability of Quantum LDPC States unde...
👉 Read on LOGIDIAS Radar
#arXiv #Science #SciSky #Physics #Physics

@logidias.bsky.socialOct 17, 2026, 8:09 AM

🔭 What if dimensions aren't just spatial? We can trap bosons in optical lattices to engineer synthetic dimensions, simulating non-Abelian gauge fields. Experience it at https://www.logidias.com/en/proyectos/materia3d.html
👉 3D Lab: Materia3D
#Science #SciSky #Chemistry #Physics

@logidias.bsky.socialOct 17, 2026, 8:09 AM

✍️ New on LOGIDIAS Blog | The James Webb Telescope: Peering into the Origin of the First Galaxies

Why must we hunt for the universe's oldest baby galaxies using infrared light? Uncover JWST's cosmic secrets.
👉 Read on logidias.com
#Science #AstronomySpace #SciSky #Physics #Blog

@punbattle.bsky.socialOct 16, 2026, 11:00 PM

No puns for Darts last round. Fresh start:

⚔️ MASHUP ROUND: FIELD TRIPS + COMPUTER VIRUSES
One pun, both topics. Most likes at 5:00 PM PDT wins 60 pts (ties split).

#PunBattle #puns #FieldTrips #ComputerViruses #WorkLife #SciSky

L@logidiases.bsky.socialOct 16, 2026, 10:03 PM

🔭 Radar arXiv del Día | Frontera Científica

¿Es posible extraer oro puro del entrelazamiento cuántico? Un nuevo avance sobre la destilación PPT desafía los límites de la física. 🔬✨

📄 "On PPT entanglement di...
👉 Ver en Radar LOGIDIAS
#arXiv #Ciencia #CienciaÑ #SciSky #Física #Física

@logidias.bsky.socialOct 16, 2026, 7:31 PM

Ignition means plasma heating itself! Packing stellar temperatures into a magnetic bottle just got a clever shortcut. #Science #SciSky #Physics 🔭

RRealClearScience@rcscience.bsky.socialOct 16, 2026, 6:51 PM

"A study in Physical Review Letters details how we might get to nuclear fusion more quickly. It outlines what is effectively a shortcut to something called ignition, where plasma can maintain the necessary heat levels through its own fusion reactions." www.realclearscience.com/2026/10/16/p...

realclearscience.comPhysicists May Have Found a Shortcut to Fusion EnergyThe Sun at the center of our own Solar System is a great advert for nuclear fusion: ultra-high temperatures and pressures combining to fuse hydrogen nuclei together into helium nuclei, releasing a hug
@logidias.bsky.socialOct 16, 2026, 7:00 PM

🔭 Imagine running at a wall and just appearing on the other side. Subatomic particles do this constantly. It's not magic—it's quantum mechanics. Test this reality in 3D: https://www.logidias.com/en/proyectos/fisiacad...
👉 3D Lab: FisiAcademia 3D
#Science #SciSky #Physics #Astrophysics

@readbentham.bsky.socialOct 16, 2026, 5:01 PM

🧠 Did You Know?

Glutamate imbalance may contribute to post-COVID cognitive and mood symptoms. Research is exploring NAC and ALC as potential therapeutic approaches.

🔗 https://bit.ly/3VSUt3U

#SciSky #AcademicSky #ResearchSky #NeuroSky

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@bioone.bsky.socialOct 16, 2026, 3:20 PM

Photo Spotlight: Cranial crests and dorsal fin rays of Regalecus shortly after its capture. Photo by Atsushi Kaneko, Okinawa Churaumi Aquarium.

Read the #OpenAccess Research published in Ichthyology & Herpetology: bio-one.co/4hFK2bm

#MarineBiology #Ichthyology #Biodiversity #Wildlife #Fish #SciSky

Ichthyology and Herpetology. Dorsal-Fin Musculoskeletal System of Oarfishes (Regalecidae): Fin Rays as Rotating Elements in an Undulatory System.
@logidias.bsky.socialOct 16, 2026, 12:30 PM

🔭 Daily arXiv Radar | Scientific Frontier

A new frontier in modern physics? This recent preprint uncovers unexpected phenomena in Frontier Science.

📄 "Quantum Channel Stein Theorem beyond Definite Causal Order"
👉 Read on LOGIDIAS Radar
#arXiv #Science #SciSky #Physics #Physics

@logidias.bsky.socialOct 16, 2026, 12:30 PM

🔭 Can pure sound tame a supersonic storm? Acoustic standing waves trap delicate droplets frozen mid-air against violent Mach winds. Master supersonic fluid dynamics in FluidLab 3D.
👉 3D Lab: FluidLab 3D & Aeronautics
#Science #SciSky #Engineering #Physics

L@logidiases.bsky.socialOct 16, 2026, 12:00 PM

🔭 Radar arXiv del Día | Frontera Científica

¿Podemos descifrar la magia de la información cuántica usando diagramas ZX y entropía de entrelazamiento? ¡Una maravilla en la física!

📄 "Entanglement entropy and...
👉 Ver en Radar LOGIDIAS
#arXiv #Ciencia #CienciaÑ #SciSky #Física #Física

@punbattle.bsky.socialOct 16, 2026, 10:00 AM

No puns for Moose + Appetites last round. Fresh start:

🎭 New pun theme: MERCURY
Reply with your best pun. Most likes at 4:00 AM PDT wins 60 pts (ties split).

#PunBattle #punny #Mercury #SciSky #dadjokes #comedy

@logidias.bsky.socialOct 16, 2026, 8:03 AM

Non-Euclidean geometry in action! If scaled to 100m, traversing those recursive steps would require infinite potential energy. #Science #SciSky #Physics 🔭

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@logidias.bsky.socialOct 16, 2026, 8:02 AM

🔭 When black holes collide, they leave a permanent scar. Spacetime doesn't bounce back; it's permanently warped forever by gravitational memory. Explore cosmic forces in 3D: https://www.logidias.com/en/proyectos/astroatla...
👉 3D Lab: AstroAtlas 3D
#Science #SciSky #Astronomy #Physics

@shimadzuuk.bsky.socialOct 16, 2026, 7:30 AM

Join Takuro Kato from Nittoseiko for a deep dive into PFAS screening using Combustion IC.

Let’s tackle environmental challenges together! 🌍

📅 18-19 Nov 2026
📍 Shimadzu UK, Milton Keynes

Secure your spot 👉https://cutt.ly/cycpiVhm

#SciSky #AcademicSky #ChemSky #EduSky #Edchat 🧪

Promotional graphic for a Shimadzu environmental testing event featuring a speaker portrait against a water-themed background. The session title is “PFAS Screening Using Combustion IC.” The speaker is Takuro Kato, Chief Technical Manager at Nittoseiko. The event is part of the "From Microplastics to PFAS: Analytical Solutions for Environmental Testing" programme and takes place on 18-19 November 2026 at the Shimadzu UK Centre of Excellence, Milton Keynes.
@beckman-foundation.bsky.socialOct 15, 2026, 9:20 PM

2025 #BSP Brice Di Carlo reflects on the #undergraduateresearch experience as a #BeckmanScholar while at #urichmond #chemsky #scisky

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@punbattle.bsky.socialOct 15, 2026, 9:00 PM

No puns for Cherries last round. Fresh start:

🎭 New pun theme: DAYS OF THE WEEK
Reply with your best pun. Most likes at 3:00 PM PDT wins 60 pts (ties split).

#PunBattle #puns #DaysOfTheWeek #SciSky #dadjokes #jokes

@logidias.bsky.socialOct 15, 2026, 7:31 PM

Growing from a stellar seed to a billion-solar-mass beast is cosmic alchemy! At the horizon, time itself freezes. #Science #SciSky #Physics 🔭