explore | Grilled Cheese

ETBF reprograms host metabolism via its B. fragilis toxin, promoting oxidative growth in the inflamed gut, shedding light on its role in colitis & cancer. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin triggers DNA damage in neurons, where nucleotide excision repair (NER) shifts from protective to detrimental, driving neuronal death. Key insights revealed. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting advances in DMD treatment: LEAPER 2.0 uses circ-arRNAs for exon skipping, achieving long-term reversal in monkeys and humans. A breakthrough in RNA editing! PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR knockout mouse library of 84 gene-modified lines enhances in vivo influenza A virus research, bridging gaps from in vitro studies to real-world insights. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how human DNA, spanning meters, fits into micrometer-scale nuclei! New study uses advanced imaging to reveal chromatin's 3D architecture in cells. PMID:42399220, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75087-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/vegetables finds garlic as a top deterrent for mating & egg-laying in Drosophila. Diallyl disulfide blocks both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel variant in situ sequencing (VIS-seq) identifies multidimensional effects of ~3,000 LMNA & PTEN variants on cell morphology, protein dynamics, and architecture. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals the VPS13A-XK complex, a bridge-like lipid-transfer protein, facilitating vesicle-independent lipid transfer between organelles, highlighting 6 key hydrophobic channels. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA 🧪

Innovative artificial metalloenzymes (ArMs) overcome cofactor inactivation, enabling novel reactions in complex biological environments. PMID:42399451, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02249-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Donor-derived CD19-CAR TSCM cells show superior expansion & persistence vs. standard CAR T cells, achieving complete responses at low doses post-HSCT relapse. PMID:42066750, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00383-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP induces membrane shearing, activating prokaryotic immunity via cyclic-oligonucleotide-based signaling. Key insights reveal the role of 3TM-SMODS in transmembrane effector mechanisms. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #RNA 🧪

It is a wrap of a wonderful week of #RNA biology at @embl.org Heidelberg for the #EESRNA, a co-chairing co-transcriptional session, lots of scientific discussions, exciting and inspiring science🤩...and some fun with a warm scientific community 🥰.
And huge thanks for the spotless organisation🙌!

PCSK5 is crucial for heart healing! Elevated in MI patients, it predicts better cardiac function. Pcsk5 deficiency in ECs impairs angiogenesis & delays repair. 🌟❤️ PMID:42399637, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-72148-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals mesenchymal cells contribute to epidermal stem cell formation in mouse skin through mesenchymal-to-epithelial transition using lineage tracing and single-cell analysis. PMID:42399254, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75278-0 #Medsky #Pharmsky #RNA 🧪

Discover high-sensitivity glycomics! seGRAP-mass spectrometry unveils a conserved N-glycome from just sub-nanogram protein inputs & picoliter human plasma. Revolutionary! PMID:42399233, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73050-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study on SOD1-G93A mice reveals that vulnerable alpha motor neurons transition to a "disease-associated" state before cell death in ALS, altering thousands of genes. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing RegVelo: a groundbreaking deep learning framework that models splicing kinetics and gene regulatory networks to reveal 42 cellular dynamics insights! PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that G-quadruplex (G4) levels influence PARP inhibitor toxicity in BRCA2-deficient cells. Elevated G4s create more DNA damage, crucial for cell survival. PMID:42399234, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75083-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats. One clade binds human ACE2. Key findings shape future viral risk assessments! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪