📢 New Review in #LiversMDPI

🧬 Tabata examines whether GGA diversion toward 2,3-diGGA may influence hepatic tumor surveillance.

🩺 The review evaluates the GGA/2,3-diGGA ratio as a candidate biomarker.

📖 Read More: www.mdpi.com/2673-4389/6/...

#GGA #HCC

TKTL1-driven #Glycolysis increases lactate and promotes #Immunosuppressive dendritic-cell signaling in #HCC. Targeting the TKTL1–HIF-1α–HK2 axis and lactate reprograms the #TumorMicroenvironment to enhance PD-1 blockade.

#STTT #OpenAccess: doi.org/10.1038/s413...

Estimador de fibrosis asoc a esteatosis (SAFE) puede informar decisiones para repetir evaluaciones de cirrosis en pac c/hepatopatía esteatósica, escalas de riesgo de CA hepatocelular tienen utilidad mínima #steatotic #liverdisease #scores #cirrhosis #HCC jamanetwork.com/journals/jam...

#ASTRO26: Theodore (Ted) Hong, MD shares phase III trial results of protons vs photons for patients with advanced #HCC.

Hypothesis: Protons would be more beneficial due to favorable dose distributions and the ability to spare non-target tissue.

💡Proton therapy did not improve OS, PFS, LP, or AEs.

🩸 How can a lipid–endothelial #signature stratify patients with #HCC?
Luxi Yang et al. explore this through an integrated multi-omics approach, linking a six-gene signature with prognosis and immune-excluded features in HCC.
🔗 buff.ly/YnGZpEo

Targeting RRM2 could tackle both #HCC and #HBV.
This study identifies HP28 and HP39 as RRM2 inhibitors that deplete dNTPs, suppress #tumor growth and HBV replication, and retain activity against sorafenib-resistant HCC.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

We have our winners!

Congratulations to Bryan Spellman, FamilyGames.Night, and Mike, our Road to 1500 Giveaway winners!

Thanks to everyone who helped Wayward Studios cross 1,500 followers.
And stay tuned, we’ve got another giveaway planned for closer to the end of the year.

#WaywardStudios #HCC

SWISS LEAGUE | Kevin Bozon practicing with HCC #HCC https://swisshockeynews.ch/en/shn/men/swiss-hockey/sl/kevin-bozon-practicing-with-hcc?utm_term=perfectpublisher&utm_campaign=social

“Hepatitis B virus protein X promotes survival and loss of hepatocyte identity in a differentiated human liver organoid system”

This physiologically relevant organoid model clarifies longstanding questions about the pathogenesis of #HBV-associated #HCC ⤵️
nature.com/articles/s41...

What keeps #βCatenin active in cancer?
This study identifies #Doublecortin as a novel regulator that stabilizes β-Catenin, enhances its transcriptional activity and promotes #HCC progression. @emorydeptofmed.bsky.social
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

SWISS LEAGUE | GSHC's Jason Akeson loaned to La Chaux-de-Fonds #HCC #GSHC https://swisshockeynews.ch/en/shn/men/swiss-hockey/sl/gshcs-jason-akeson-loaned-to-la-chaux-de-fonds?utm_term=perfectpublisher&utm_campaign=social

How can advances in #HCC care reach more patients across Europe?

The Series highlights the need for coordinated approaches across prevention, surveillance, treatment, reimbursement, and policy to reduce disparities and improve outcomes.

As the causes of #HCC change, so must Europe’s response.

Our Series explores how #MASLD, alcohol-related liver disease, and an ageing population are reshaping prevention, early detection, clinical practice, and health policy.

The landscape of hepatocellular carcinoma in Europe is changing.

Chaired by Prof David Pinato, the Series examines the evolving #HCC burden, persistent surveillance gaps, advances in treatment and inequalities in access to care.

Read more 👇
shorturl.at/qo8g1

MEDICAL REPORT | HCC's Christian Pinana injured #HCC https://swisshockeynews.ch/en/shn/medical/hccs-christian-pinana-injured?utm_term=perfectpublisher&utm_campaign=social

📢 New Review in #LiversMDPI

🧬 Jones et al. examine HCC complexity and therapeutic challenges, focusing on HuR.

🩺 Preclinical evidence supports HuR inhibition as a potential strategy in HCC.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HCC #HuR #TherapeuticResistance

MEDICAL REPORT | HCC without David Eugster for months, Janik Loosli ready for comeback #HCC https://swisshockeynews.ch/en/shn/medical/hcc-without-david-eugster-for-months-janik-loosli-ready-for-comeback?utm_term=perfectpublisher&utm_campaign=social

6/ 💡 Together, the study expands the landscape of potential HCC antigens beyond the canonical proteome and provides a framework for discovering and validating ncORF-derived targets for cancer immunotherapy.

#LiverCancer #HCC #CancerImmunotherapy #Immunopeptidomics

How does #HCC withstand #OxidativeStress during therapy?

This study identifies a HIF1α–KLF4–hemoglobin axis that scavenges ROS and promotes sorafenib resistance, revealing a targetable redox adaptation.

#STTT #OpenAccess: doi.org/10.1038/s413...

#TumorHypoxia #TherapyResistance #CancerBiology