By studying how each enzyme evolve to become faster and more stable, he is learning the rules for designing proteins that are both powerful and tough, and using them to guide the next round of designs.

#ProteinDesign #CarbonCapture #EnzymeEngineering #Biotechnology #CRISPR

5/5

Deleting the AF-2 domain of the BmERR receptor in silkworms suppressed the expression of melanin synthesis genes. This confirmed that insect metabolic regulation requires coactivators.

#Crispr #GeneEditing #Metabolism

Our paper, “Programming CRISPR Compartmentalization on DNA Origami for Multiplexed Biosensing” is now out in Analytical Chemistry
Many thanks to Chunhai Fan, Qian Li, and Zhilei Ge for the great collaboration, and I’m grateful for the amazing experience at Shanghai Jiao Tong University! #DNA #CRISPR

🚀 Big buzz at #ASGCT25: #GeneEditing & #CRISPR headlines, 20% data-driven talk, 85% positive vibes on breakthrough therapies for #DMD & #rarediseases!🧬 Download our full #socialmedia report! http://dlvr.it/TVt82T #GeneTherapy #SocialListening #LucidQuest
@ASGCTherapy @ESGCT

#VegetableRes
Genome-wide analysis identifies 13 DMP genes in radish; CRISPR/Cas9 editing of RsDMP9 validated.
Details: https://www.maxapress.com/article/doi/10.48130/vegres-0026-0015
#Radish #CRISPR #GeneEditing

Scientists Debate Anthropic’s Claim of an AI-Led DNA Discovery

🤖 IA: It's not clickbait ✅
👥 Users: It's not clickbait ✅

#biology #crispr

👇👇👇

El segundo artículo se ha publicado en @cellcellpress.bsky.social y muestra el camino a lo largo del desarrollo que siguen 1,4 millones de células de embriones de ratón, marcadas con el sistema PEtracer derivado de #CRISPR prime editing (edición de calidad).

www.cell.com/cell/fulltex...

Dos artículos científicos muestran el uso de técnicas de edición genética #CRISPR para marcar y seguirles la pista a células durante el desarrollo temprano de embriones de ratón. Han descifrado el pedigree y la ruta de muchos tipos celulares iniciales. @science.org
www.science.org/content/arti...

CRISPR repurposed from cutting DNA to recording it: two teams traced a mouse from fertilised egg to late-stage embryo, cell by cell. #CRISPR #Genetics #DevelopmentalBiology #Science

https://freegardner.com/sci_scout/crispr-records-mouse-embryo-development-cell-by-cell.html

Seung Hwan Lee’s team developed dBhCas12b-ABE, a Cas12b adenine base editor targeting T-rich PAMs that suppresses indels to 0–0.04% and offers tunable editing windows. 🧬🤖 #CRISPR #BaseEditing #Cas12b #MolecularTherapy #GeneEditing #ChungAngUniversity

⏩ Possible projects are: variational #freeenergy methods, thermodynamics of #solvationshells, #constant-pH simulation methods, Markovian #thermodynamics, as well as functional mechanisms of the #ribosome, fatty acid synthase, #CRISPR/Cas, or intrinsically disordered proteins #IDP

📢 PhD alert! Funded 4-year PhD with @aries-dtp.bsky.social at @uniofeastanglia.bsky.social. Medfly mothers coat their eggs in antimicrobial peptides. #CRISPR, #microbiome sequencing: aries-dtp.ac.uk/studentships...
📅 Deadline: 16 Dec 2026
🎓 Start: 1 Oct 2027
#PhD #[email protected]

#Science #CRISPR

#CAS researchers developed a lambda Red-assisted #CRISPR/Cas9 editing system in #Agrobacterium tumefaciens, achieving up to 100% precise editing efficiency and engineering immune-evading strains that boost plant transformation. 🌿🤖 #PBJ2026 #PlantBiotech #GenomeEditing

#Jiayang Li and Hong Yu’s team used #CRISPR promoter saturation editing on OsHMA3 to disrupt repressor OsRF2b binding, creating a transgene-free knock-up allele that reduces rice grain cadmium by 40.7% with zero yield penalty. 🌾🤖 #RiceGenomics #PlantBiotech2026 #CadmiumSafety #PromoterEditing

Aus 2024 gibt es noch eine tolle #Riffreporter Podcast Folge zum Thema #Crispr

open.spotify.com/episode/1lN0...

Allgemein kann ich den Podcast der Riffreporter allen empfehlen.

(auch auf anderen Plattformen hörbar)

Zum ersten Mal nach der Zulassung einer auf der Genschere #CRISPR basierenden Therapie ist laut Charité ein Patient mit genetisch bedingter Bluterkrankung Beta-Thalassämie in Dtl. erfolgreich damit behandelt worden.

Der Patient ist nach der Behandlung nicht mehr von Bluttransfusionen abhängig.

🧬 What if CRISPR, enzyme engineering & synthetic biology could redefine biocatalysis?

Explore gene editing, metabolic pathway optimization, rapid strain development & scalable production at BCBTC 2027, Singapore, March 25–26. 🌱

#BCBTC2027 #Biocatalysis #CRISPR

"maybe if you lost some #weight, you could take less of them pills"

I'm sorry?

do you think me losing weight will change my #GENETICPREDISPOSITION TO #MENTALILLNESS????

unless you have a magic #CRISPR machine in the back, I'm still gonna be mentally ill if I lose weight

SHUT UP