A novel variant in situ sequencing (VIS-seq) identifies multidimensional effects of ~3,000 LMNA & PTEN variants on cell morphology, protein dynamics, and architecture. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative artificial metalloenzymes (ArMs) overcome cofactor inactivation, enabling novel reactions in complex biological environments. PMID:42399451, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02249-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Donor-derived CD19-CAR TSCM cells show superior expansion & persistence vs. standard CAR T cells, achieving complete responses at low doses post-HSCT relapse. PMID:42066750, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00383-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

PCSK5 is crucial for heart healing! Elevated in MI patients, it predicts better cardiac function. Pcsk5 deficiency in ECs impairs angiogenesis & delays repair. 🌟❤️ PMID:42399637, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-72148-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover high-sensitivity glycomics! seGRAP-mass spectrometry unveils a conserved N-glycome from just sub-nanogram protein inputs & picoliter human plasma. Revolutionary! PMID:42399233, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73050-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study on SOD1-G93A mice reveals that vulnerable alpha motor neurons transition to a "disease-associated" state before cell death in ALS, altering thousands of genes. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing RegVelo: a groundbreaking deep learning framework that models splicing kinetics and gene regulatory networks to reveal 42 cellular dynamics insights! PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that G-quadruplex (G4) levels influence PARP inhibitor toxicity in BRCA2-deficient cells. Elevated G4s create more DNA damage, crucial for cell survival. PMID:42399234, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75083-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats. One clade binds human ACE2. Key findings shape future viral risk assessments! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, enhancing predictions of cell fate with potential regulators shaping 10^3 cell-state changes. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel model replays 100+ GC reactions, revealing how B cell competition enhances antibody affinity through a quantified affinity landscape—transformative insights in immunology! PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG 🧪

LEAPER 3.0 leverages endogenous ADAR for precise RNA editing using engineered RNAs, improving efficiency with insights from AlphaFold 3. Stunning potential! PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neutrophil stages in acute heart conditions reveal stratified survival insights; all groups show immature neutrophils, especially STEMI. PMID:42399420, Nat Cardiovasc Res 2026 https://doi.org/10.1038/s44161-026-00836-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that prion-based protein self-assembly in S. cerevisiae leads to rapid mutagenesis adaptation, enabling evolution in various ecological settings. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, significantly enhancing prevention trial efficacy and addressing high NNT issues. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals CDK11's role in spliceosome activation and DHX15's proofreading. Discoveries made through SF3B1 phosphorylation insights and inhibitor OTS964 effects. PMID:42399621, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75109-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Recent work in @hggadvances.bsky.social uses systems genetics in BXD mice to identify transcriptional networks and candidate genetic regulators that control cardiac iron homeostasis, offering new insights into the genetic basis of iron-related heart disease: https://bit.ly/4hFiGTS #ASHG

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, hinting at a possible single-sex sample. Exciting findings! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals the structure of the moving junction in Plasmodium falciparum: a 1:1:1:1 assembly of PfAMA1 & PfRON2, 4, 5. Key for invasion! PMID:42379167, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00699-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing treatments: a deep learning method uses de novo protein WRAPs to solubilize membrane proteins, enhancing analysis! PMID:42391386, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adr3817 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪