Cysteine's sulfur splits pathways for growth: it fuels GSH and Fe-S clusters, enhancing CD8⁺ T cell proliferation and anti-tumor immunity—metabolic choice matters! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 safeguards the reprogramming of human somatic cells to pluripotency by ensuring genome stability, balancing risk through regulation of the Yamanaka factors. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🔬 Bulk #RNA-seq is widely used in biological research, but #dataanalysis can be a hurdle.
Our FGEz pipeline delivers reliable, high-quality results from your RNA-seq data.
Discover more at:
https://www.fiosgenomics.com/bulk-rna-sequencing-analysis-using-fgez

Centre National de la Recherche Scientifique is hiring:
Postdoctoral Researcher in RNA and Translation

#postdoc #chemsky #rna

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts after CANTOS showed IL-1β inhibition benefits. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionary seqFISH+ spatial transcriptomics mapped 2,653 genes in 867,062 mouse testis cells, revealing Sertoli cells' unique cyclic transcription aligned with sperm development! PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG 🧪

Want to get up to date on the latest in #RNA sensing and #virus infections? Lucky for you, we just published a review!

Led by my talented PhD student Sofia Maceratessi, we've reviewed new discoveries in the field in the last 2-3 years.

Read it here: onlinelibrary.wiley.com/doi/10.1111/...

New research reveals TMEM154/Galvanin as a key receptor enabling cells to detect electric fields, directing migration towards the cathode, pivotal for cell behavior. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery reveals GPNMB CAR T cells targeting multiple cancers. The approach uses single-cell RNA-seq, refining candidates to enhance tumor targeting. Exciting leap for immunotherapy! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #RNA 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium, driven by IL-6 during E. coli infection, boosts nociceptive pathways and chronic pain via SLC7A11-glutamate. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study maps ~89,000 genetic interactions in HAP1 cells from ~4M CRISPR perturbations, revealing hierarchical modules that clarify gene co-essentiality. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on VPS13A, a bridge-like lipid transfer protein, reveal its complex with scramblase XK, illuminating lipid transfer mechanisms at organelle contact sites! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Primate organogenetic embryoids created from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveal key totipotent features, advancing embryonic development models. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A unique type of parvalbumin-expressing inhibitory neurons in the basal forebrain enhances sustained attention, revealing a new neural circuit beyond cholinergic neurons. #Attention PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪

Systematic CRISPR screens in primary CD4+ T cells unveil 25+ pro- and anti-HIV factors, revealing diverse antiviral mechanisms and targeting strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method, VIS-seq, analyzes 3,000 LMNA & PTEN variants, revealing complex, disease-specific effects on cell phenotypes through high-dimensional imaging. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New #Reproducibility Certification:

Anchored Augmentation: Constructing Training Data for Deep Cellular Deconvolution from Paired Pil...

Jason Thomo, Yushan Hu, Alex Thomo, Xuekui Zhang

https://openreview.net/forum?id=FG7PlICeut

#rna #2drna #bulk

#解剖生理学を独学できるYouTube動画

メディカルロックティーチャーリョウによる
「#解剖生理学」シリーズ
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超絶よくわかる！！#細胞 つくりと働き完全版！！#ミトコンドリア #ナトリウムチャネル #DNA #RNA #リボソーム【解剖生理学58】【#高校生物】
https://www.youtube.com/watch?...

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The recording of the latest Molecular Presents webinar, AI-Powered Precision Medicine: From Biomarker Discovery to Therapeutic Design and Delivery, is now available!

Watch it here today: http://dlvr.it/TVmhly

#AI #MachineLearning #RNA #ASGCT

A study reveals that 3D morphogenetic processes drive metastatic outgrowth in breast cancer. Macrometastases activate a specific gene-expression program, transforming development pathways into lethal growth. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #RNA 🧪