New research reveals TMEM154/Galvanin as a key receptor enabling cells to detect electric fields, directing migration towards the cathode, pivotal for cell behavior. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium, driven by IL-6 during E. coli infection, boosts nociceptive pathways and chronic pain via SLC7A11-glutamate. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study maps ~89,000 genetic interactions in HAP1 cells from ~4M CRISPR perturbations, revealing hierarchical modules that clarify gene co-essentiality. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights on VPS13A, a bridge-like lipid transfer protein, reveal its complex with scramblase XK, illuminating lipid transfer mechanisms at organelle contact sites! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Primate organogenetic embryoids created from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveal key totipotent features, advancing embryonic development models. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A unique type of parvalbumin-expressing inhibitory neurons in the basal forebrain enhances sustained attention, revealing a new neural circuit beyond cholinergic neurons. #Attention PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪

Systematic CRISPR screens in primary CD4+ T cells unveil 25+ pro- and anti-HIV factors, revealing diverse antiviral mechanisms and targeting strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method, VIS-seq, analyzes 3,000 LMNA & PTEN variants, revealing complex, disease-specific effects on cell phenotypes through high-dimensional imaging. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Data Resource Profile: Medicines in Acute and Chronic Care in Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿 (MACCS) academic.oup.com/ije/article/...

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Single-cell D&D-seq reveals precise DNA-protein interactions, unlocking insights into gene regulation by TFs. This tool transforms understanding of chromatin dynamics. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear and cytosolic proteomics of NSCs reveal abundant cytoskeletal proteins like MAP1B, which shuttle to the nucleus, linking microtubule dynamics to cellular fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A new model reveals how physical constraints shape the intricate topology of mammalian cortical connectomes, highlighting unique regional connectivity profiles. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study uncovers xenophagocytosis, where host macrophages eliminate xenogeneic donor cells in organ transplantation. Blocking this process increases interspecies chimerism! PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal that environmental allergens boost intracellular iron via PAR1-dependent ferritinophagy, activating GSDMD and triggering inflammatory IL-33 release in airway cells. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA 🧪

Study reveals FET proteins and PARylation aid DNA repair. Upon PARG inhibition, replication fork reversal occurs. Key in cancer therapy. Insights into genome stability! PMID:42380136, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74950-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing via 3TM proteins in the CBASS antiviral system, revealing key mechanisms in prokaryotic immunity against phages. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Studying neo-polyploid Arabidopsis kamchatica: detailed genomes of progenitors A. halleri & A. lyrata reveal immediate DNA methylation & gene expression shifts post-polyploidization. PMID:42380194, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75042-4 #Medsky #Pharmsky #RNA 🧪

A simple test could solve the overprescription crisis

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www.thetimes.com/article/dc4a...

A phytoscreen of 43 fruits & veggies found garlic a strong deterrent of mating & egg-laying in Drosophila. Diallyl disulfide blocked both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover PRIME: a hybrid deep learning tool to pinpoint metal-binding sites in metalloproteins with unmatched accuracy. Revolutionizing studies with complex proteins! 🔬 PMID:42380105, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74657-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪