Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation and chronic pain during uropathogenic E. coli infection through IL-6 signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG 🧪

Study shows promising results: Neoadjuvant fulvestrant + abemaciclib achieves high clinical benefit rate in advanced low-grade serous ovarian carcinoma. Insightful findings! PMID:42374029, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74571-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery of GPNMB CAR T cells could transform multi-cancer therapy, optimizing target identification from 1000s of single-cell RNA sequences. Exciting potential! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Key findings reveal that MBS1, a mediator of 1O2 responses, forms protein condensates in chloroplasts, enhancing high-light tolerance and protecting against photodamage. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Fuel Future Discoveries, One Step at a Time. Join #ASHG's Fit for the Future of Human Genetics fundraising campaign, turning your everyday movement into meaningful support for trainees & early-career researchers facing financial barriers. Get involved:
https://bit.ly/4dfkNLA #ASHG #HumanGenetics

3D diffusion autoencoders analyze cardiac MRI data from 71,017 UK Biobank participants, unveiling reproducible, heritable phenotypes (h² = 4–18%). Fascinating insights! PMID:42373625, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74575-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing embryonic research: Primates' organogenetic embryoids from cTBLCs showcase totipotent features, advancing models from zygote to early organogenesis. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research in @hggadvances.bsky.social's shows that MED13L variants disrupt mitochondrial function, uncovering an intersection between transcriptional control & mitochondrial homeostasis with implications for future therapeutic development: https://bit.ly/4hjIchn #ASHG #humangenetics

A 14-protein plasma signature predicts lung cancer risk >5 years before diagnosis, enhancing prevention strategies beyond IL-1β inhibition's high NNT. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring >20 neuronal autoantibodies in diagnosing autoimmune encephalitis can transform treatment approaches. Discuss! 🔍🧠 PMID:42371614, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2027 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

In @ajhgnews.bsky.social's latest article, the authors highlight recent progress integrating genomics into newborn screening programs & discuss persistent challenges in standardization, scale, and equity: https://bit.ly/3V6KiZn #ASHG #humangenetics #geneticsdiscoveries

Systematic CRISPR screens in human CD4+ T cells found 43 pro- and 91 anti-HIV host factors, unveiling diverse antiviral mechanisms and potential therapeutic targets. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway detects dsDNA, linking innate immunity to tissue homeostasis and antitumor activity. Its role in inflammation opens new therapeutic avenues. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies MARCH7 as a key E3 ubiquitin ligase that regulates intracellular iron, acting as a dual suppressor of ferroptosis by ubiquitylating NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

3'-UTR variants influence mRNA regulation, impacting alcohol use disorder risk. #GeneticsInFocus PMID:42374457, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-04176-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switches in DNA repair proteins drive adaptive mutagenesis in Saccharomyces cerevisiae, enhancing evolution across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress boosts susceptibility to metabolic dysfunction when followed by an obesogenic diet in mice, driven by KLK14's impact on hypothalamic LRRC7⁺ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals >1,000 molecular changes in SOD1-G93A mouse motor neurons, leading to a new "disease-associated motor neuron" state, key to ALS progression. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel screening platform using 84 CRISPR-Cas9 mouse lines targets host factors crucial for understanding influenza A virus. This boosts in vivo functional validation! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/vegetables revealed garlic as a key deterrent of mating and egg laying in Drosophila and mosquitoes. Diallyl disulfide disrupts these behaviors! 🍏🦟 PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪