Study finds TCF1 alone doesn't define stem-like T cells in chronic disease; LEF1 and niche factors also crucial for T cell stemness in autoimmunity & chronic infection. #TcellResearch PMID:42385703, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00709-9 #Medsky #Pharmsky #RNA 🧪

Shining light on congenital myasthenia: correcting acetylcholine receptor mutations may improve muscle function and transform lives. Are breakthroughs near? PMID:42386970, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10706-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals Arc is essential for tau release via extracellular vesicles; rTg4510/Arc KO mice show reduced tau and seeding potential—key insights into neurodegeneration! PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how treatment thresholds in psychiatry are reshaped by clinimetric advances; key for optimized patient care in 2023. PMID:42384391, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1759 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

DNA hypomethylation in tomatoes aids SlSPL-CNR to bind and repress SlAAT1, altering f… PMID:42386734, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-75181-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: 27 volunteers challenged with A/H3N2, 22 infected, 18 symptomatic. Rapid innate immune response linked to symptoms. PMID:42387215, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04483-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Xenophagocytosis, where host macrophages eliminate xenogeneic donor cells due to elevated phosphatidylserine, can be blocked to boost interspecies chimerism and tackle organ shortages. PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA 🧪

Explore the role of NUDT5 in 6-TG response; inhibition matters more than loss, boosti… PMID:42380098, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74489-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of fertilized eggs stall in early development, mainly due to error-prone 2nd mitotic divisions. Transient PLK4 inhibition reduces centriole overduplication, boosting efficiency. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

Discover how the IDP ALMS1 influences centriole biogenesis! It catalyzes cartwheel formation by organizing CEP152 without becoming part of the structure itself. PMID:42380124, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74821-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New trimodal platform enables simultaneous in vivo Ca²⁺ imaging, neuron morphology reconstruction, and in situ transcriptomic profiling, advancing neuron function insights. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RESEARCH PAPER: rRNA 5′ETS processing contributes to nucleolar organization and nuclear architecture
By Mendoza-Figueroa et al. and Kathy Fange Liu
➡️ https://genesdev.cshlp.org/content/40/19-20/1614.abstract

@kathyliulab.bsky.social University of Pennsylvania Penn Medicine
#RNA #nucleus #genome

Cuproptosis, a copper-dependent cell death, enhances tumor susceptibility in CD8+ T-cells, revealing a potential strategy to boost immunotherapy efficacy through immunogenic cell death. PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #Medsky #Pharmsky #RNA 🧪

Alzheimer's disease shows over 1,000× enrichment of somatic mutations in cancer driver genes, especially in those linked to clonal hematopoiesis, driving microglial expansion! PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel in vivo screening platform was created using 84 CRISPR-Cas9 knockout mouse lines to validate host factors in influenza A research, bridging vital gaps in virology! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🆕 Introducing EZCollect from Norgen Biotek
A new solution designed to simplify home-based stool collection and nucleic acid preservation.

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#EZCollect #Microbiome #SamplePrep #DNA #RNA #NorgenBiotek

A recent study on recurrent GBM highlighted that CAR T cell therapy showed early promise but nearly 50% relapse rates indicate a crucial role for immune response in outcomes. PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur splits pathways for growth: it fuels GSH and Fe-S clusters, enhancing CD8⁺ T cell proliferation and anti-tumor immunity—metabolic choice matters! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 safeguards the reprogramming of human somatic cells to pluripotency by ensuring genome stability, balancing risk through regulation of the Yamanaka factors. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪