Cardiovascular risk reduction - quality prescribing guidance 2026-2029: consultation 🏴󠁧󠁢󠁳󠁣󠁴󠁿

#Pharmsky

www.gov.scot/publications...

New trimodal platform enables simultaneous in vivo Ca²⁺ imaging, neuron morphology reconstruction, and in situ transcriptomic profiling, advancing neuron function insights. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study on SOD1-G93A mice reveals thousands of changes in vulnerable α-motor neurons, leading to a distinct state termed "disease-associated motor neurons" (DMs) before cell death in ALS. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky 🧪

Join ASPET for a webinar where faculty and graduate students from Boston University School of Medicine share what to expect from their pharmacology program. Register: https://ow.ly/Enz950ZUqQp
This webinar is open to anyone interested in learning about graduate-level pharmacology!
#pharmsky 🧪

Join ASPET for a webinar where faculty and graduate students from Boston University School of Medicine share what to expect from their pharmacology program. Register: https://ow.ly/Enz950ZUqQp
This webinar is open to anyone interested in learning about graduate-level pharmacology!
#pharmsky 🧪

Cuproptosis, a copper-dependent cell death, enhances tumor susceptibility in CD8+ T-cells, revealing a potential strategy to boost immunotherapy efficacy through immunogenic cell death. PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #Medsky #Pharmsky #RNA 🧪

Galvanin (TMEM154), a novel single-pass transmembrane protein, is essential for immune and epithelial cells sensing electric fields (EF) for directed migration, crucial for wound healing. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky 🧪

Alzheimer's disease shows over 1,000× enrichment of somatic mutations in cancer driver genes, especially in those linked to clonal hematopoiesis, driving microglial expansion! PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel in vivo screening platform was created using 84 CRISPR-Cas9 knockout mouse lines to validate host factors in influenza A research, bridging vital gaps in virology! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Advocate for science policy! ASPET’s Government Affairs and Science Policy staff will visit you and your staff, or meet with you virtually, and provide on-hands guidance on how your voice can be heard.

Learn how to arrange a visit this fall or next spring: https://ow.ly/meZ750ZTxbz
#pharmsky 🧪

Advocate for science policy! ASPET’s Government Affairs and Science Policy staff will visit you and your staff, or meet with you virtually, and provide on-hands guidance on how your voice can be heard.

Learn how to arrange a visit this fall or next spring: https://ow.ly/meZ750ZTxbz
#pharmsky 🧪

A recent study on recurrent GBM highlighted that CAR T cell therapy showed early promise but nearly 50% relapse rates indicate a crucial role for immune response in outcomes. PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur splits pathways for growth: it fuels GSH and Fe-S clusters, enhancing CD8⁺ T cell proliferation and anti-tumor immunity—metabolic choice matters! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 safeguards the reprogramming of human somatic cells to pluripotency by ensuring genome stability, balancing risk through regulation of the Yamanaka factors. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts after CANTOS showed IL-1β inhibition benefits. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Groundbreaking whole-cell digital twin framework integrates 4D lattice light-sheet data for real-time simulation of intracellular dynamics, revealing complex interactions in 27 organelles! 🚀 PMID:42379169, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00697-5 #Medsky #Pharmsky 🧪

Revolutionary seqFISH+ spatial transcriptomics mapped 2,653 genes in 867,062 mouse testis cells, revealing Sertoli cells' unique cyclic transcription aligned with sperm development! PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG 🧪

New research reveals TMEM154/Galvanin as a key receptor enabling cells to detect electric fields, directing migration towards the cathode, pivotal for cell behavior. PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium, driven by IL-6 during E. coli infection, boosts nociceptive pathways and chronic pain via SLC7A11-glutamate. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study maps ~89,000 genetic interactions in HAP1 cells from ~4M CRISPR perturbations, revealing hierarchical modules that clarify gene co-essentiality. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪