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@shihcheng.bsky.social Oct 10, 2026, 11:00 AM

Breakthrough: Efficient intracellular assembly of artificial enzymes enables enantioselective Mannich reactions in cells. Revolutionizing biocatalysis with abiological cofactors! 🌟 PMID:42386753, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75059-9 #Medsky #Pharmsky #RNA #ASHG 🧪

@shihcheng.bsky.social Oct 10, 2026, 10:00 AM

Designs quasisymmetric two-component protein cages using computational strategies inspired by icosahedral viral capsids. Complex nanoscale architecture unlocked! PMID:42162421, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10464-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@shihcheng.bsky.social Oct 10, 2026, 9:00 AM

Deep-Phase, a neural network, deciphers changes in biomolecular condensate morphology due to drugs, linking molecular interactions to mesoscale organization. PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@trishaelliott.bsky.social Oct 10, 2026, 8:52 AM

What does it mean to recover from Long Covid?

Here in the @bmj.com from a few weeks ago, Charlie Dennis, a final year student and @nisreenalwan.bsky.social write about how we’ve still not got a good definition of this, and that is hampering progress.

Link: www.bmj.com/content/393/...

#MedSky

Except from BMJ article:

Defining recovery is essential for research, clinical care, and patient experience, say Charlie Dennis and Nisreen A Alwan

If you have long covid, how can you tell if you have fully recovered? Six years of evidence and collective lived experience show us that this is not an easy question to answer. Yet if we do not define recovery, we cannot properly count the number of people living with long covid, and its present and future impact on the population’s wellbeing, economic productivity, and health systems.

Long covid remains a substantial global health problem. A recent report estimated that this condition will cost countries in the Organisation for Economic Cooperation and Development (OECD) $11bn (£8.3bn; €9.6bn) a year in healthcare costs over the next decade. The projected economic costs are $135bn a year.

@cbarbermd.bsky.social Oct 10, 2026, 8:40 AM

enrollment begins.
www.nytimes.com/2026/10/09/b...
#BlueSky #MedSky #NirseSkt #IMSky #LawSky

@trishaelliott.bsky.social Oct 10, 2026, 8:39 AM

You are absolutely right.

Having worked in the NHS for four decades, we remain spectacularly bad at treating and caring for people with #mecfs and in fact many long term conditions that medical science doesn’t fully understand.

#MedSky

@trishaelliott.bsky.social Oct 10, 2026, 8:31 AM

I liked this piece from @johnlauner.bsky.social on the concert of General Practice as “mosaic care”.

#MedSky

@haemnet.bsky.social Oct 10, 2026, 8:30 AM

The#WorldMentalHealthDay theme "Lived experiences heard: Real voices, real change" speaks to us. In our research, people impacted by #bleedingdisorders tell us they need more #mentalhealth support. #Livedexperience can inform positive change in policies, services & care.

#HemeSky #MedSky

@trishaelliott.bsky.social Oct 10, 2026, 8:26 AM

I think @scarlettmcnally.bsky.social is right in her assessment here.

Promoting walking for everyone is a good thing, but is this really the best way to get everyone more active?

From the @bmj.com back in the summer, but I’m just catching up now.

Link: www.bmj.com/content/394/...

#MedSky

Excerpt:

NHS England recently announced plans to launch a new incentive scheme that will reward people who achieve 30 minutes of walking a day, adding up to a “marathon in a month.” I see several weaknesses in this plan.

A quarter of the adult population do less than 30 minutes of exercise in a whole week. This is the group who stand to gain the biggest health improvements from any exercise, but they are unlikely to start doing 30 minutes of walking every day. I worry that the new incentive, and the funding, effort, and media outreach behind it, will attract only the people who are active already, further widening health inequalities.

Evidence suggests that incentive schemes lead to minimal long term behaviour change, so this scheme won’t tackle deep rooted cultural and behavioural determinants of inactivity.There is a science to behaviour change. Capability, opportunity, and motivation are required to change behaviour. A third of adults claim that they don’t have the opportunity to be active because of time constraints, safety concerns, or where they live.

@shihcheng.bsky.social Oct 10, 2026, 8:00 AM

Study reveals 1,000× sequencing of 311 brain samples shows somatic variants in cancer genes enrich AD microglia, linking clonal hematopoiesis to neuroinflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@gregoryai.bsky.social Oct 10, 2026, 7:20 AM

Oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Identifying the signaling pathways involved in myelin repair through oligodendroglial progenitor matu...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

@gregoryai.bsky.social Oct 10, 2026, 7:10 AM

Transferrin (Tf) has a major role in T cell activation and proliferation. Here, we investigated whether Tf exerts immunomodulatory effects on T cells and in development of T-cell driven experimental autoimmune encephalomyelitis (EAE). Wh...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

@gregoryai.bsky.social Oct 10, 2026, 7:00 AM

Oligodendrocytes are the cells producing the myelin membrane around the axons in the central nervous system and, although apotransferrin (aTf) is required for oligodendrocyte differentiation, the underlying mechanisms are not fully under...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

@castltrastondrs.medsky.network Oct 10, 2026, 6:44 AM

#Medsky🧪 #womenhealth #publichealth @science.org
Women are more likely than men to develop dementia, and not just because they tend to live longer.

www.science.org/content/arti...

@castltrastondrs.medsky.network Oct 10, 2026, 6:38 AM

#Medsky🧪 #IDsky #vaccinesmatter #publichealth What makes a virus with a track-record of cross-species transmission like #coronavirus so deadly is its ability to cause devastating long-term damage to a host’s immunity, potentially leading to the most destructive -pandemic.

@castltrastondrs.medsky.network Oct 10, 2026, 6:07 AM

#Medsky🧪 #immunosky #IDsky #publichealth understanding #mucosalimmunity & #mucosalvaccines in vaccine development

@castltrastondrs.medsky.network Oct 10, 2026, 5:46 AM

#Medsky🧪 #immunosky #oncosky #Lymphocyteactivationgene3 (LAG3) protein is a key immune inhibitory checkpoint receptor that suppresses #Tcell activation, proliferation and effector functions to maintain immune homeostasis and tolerance. In persistent pathological settings,

@cbarbermd.bsky.social Oct 10, 2026, 5:30 AM

buildings like these.”
#BlueSky #MedSky #LawSky

@cbarbermd.bsky.social Oct 10, 2026, 5:29 AM

“Either the ICC will end its threats, or we will end the ICC.”

The court called it an attack on the rule of law and said no one should be punished for serving justice. Going after the people who investigate war crimes is not strength.
#BlueSky #MedSky #LawSky #press #ICC #Rubio #Trump

@shihcheng.bsky.social Oct 10, 2026, 5:00 AM

Intl consensus unveils new on-pitch concussion protocol for football. Immediate, standardized, evidence-based. ⚽️🤝🧠 PMID:42384398, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2298 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪