p53 is crucial for safe and efficient reprogramming of human somatic cells to pluripotency, balancing genome stability while opposing oncogenic risks. #p53 PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Here’s what you need to know about CARBAPENEM ANTIBIOTICS from an ICU pharmacist in 60 seconds!

#Medsky #Pharmsky

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying 100+ potential regulators influencing cell fate changes. Exciting times ahead! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Can the AMA start going after AI about scope creep and leave us alone?

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finance.yahoo.com/healthcare/a...

New insights from single-cell and multi-omics reveal 10 unique senotypes in human tissues linked to aging and disease, paving the way for 5 targeted senotherapeutic strategies. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Study finds TCF1 alone doesn't define stem-like T cells in chronic disease; LEF1 and niche factors also crucial for T cell stemness in autoimmunity & chronic infection. #TcellResearch PMID:42385703, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00709-9 #Medsky #Pharmsky #RNA 🧪

Our latest #PrimaryCare research newsletter (October 2026) is out now! 📢

It includes:

✅new research findings
✅blogs & opinion
✅people news
✅events
✅recruiting studies

👉See: tinyurl.com/3uhb7zva
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Shining light on congenital myasthenia: correcting acetylcholine receptor mutations may improve muscle function and transform lives. Are breakthroughs near? PMID:42386970, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10706-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals Arc is essential for tau release via extracellular vesicles; rTg4510/Arc KO mice show reduced tau and seeding potential—key insights into neurodegeneration! PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how treatment thresholds in psychiatry are reshaped by clinimetric advances; key for optimized patient care in 2023. PMID:42384391, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1759 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

DNA hypomethylation in tomatoes aids SlSPL-CNR to bind and repress SlAAT1, altering f… PMID:42386734, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-75181-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: 27 volunteers challenged with A/H3N2, 22 infected, 18 symptomatic. Rapid innate immune response linked to symptoms. PMID:42387215, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04483-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Xenophagocytosis, where host macrophages eliminate xenogeneic donor cells due to elevated phosphatidylserine, can be blocked to boost interspecies chimerism and tackle organ shortages. PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA 🧪

Explore the role of NUDT5 in 6-TG response; inhibition matters more than loss, boosti… PMID:42380098, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74489-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of fertilized eggs stall in early development, mainly due to error-prone 2nd mitotic divisions. Transient PLK4 inhibition reduces centriole overduplication, boosting efficiency. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

Discover how the IDP ALMS1 influences centriole biogenesis! It catalyzes cartwheel formation by organizing CEP152 without becoming part of the structure itself. PMID:42380124, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74821-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Gravity isn't just pulling us down—it's boosting mitochondria! In microgravity, mitochondrial translation drops in both mammals and C. elegans. How does gravity influence this crucial process? PMID:42380108, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74493-z #Medsky #Pharmsky 🧪

Cardiovascular risk reduction - quality prescribing guidance 2026-2029: consultation 🏴󠁧󠁢󠁳󠁣󠁴󠁿

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www.gov.scot/publications...

New trimodal platform enables simultaneous in vivo Ca²⁺ imaging, neuron morphology reconstruction, and in situ transcriptomic profiling, advancing neuron function insights. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study on SOD1-G93A mice reveals thousands of changes in vulnerable α-motor neurons, leading to a distinct state termed "disease-associated motor neurons" (DMs) before cell death in ALS. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky 🧪