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@prepub-neurodegen.bsky.socialOct 7, 2026, 4:03 PM

1H, 13C, and 15N chemical shift assignments of monomorphic Aβ1-40 at 100 kHz MAS in a diamond rotor #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11089530/latest

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:03 PM

Sublaterodorsal tegmental nucleus α-Synuclein seeding uncouples neuropathology from Parkinson's disease- relevant functional deficits in wild-type mice #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11272427/latest

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:03 PM

CogAlign-CausalX: mask-grounded polyp analysis with closed-form explanation-alignment scoring #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11101497/latest

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:03 PM

Environmental Contamination and Exposure Pathways of Toxic Metals in ASGM Areas in Ghana: A Multi-Regional Assessment #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10854105/latest

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:03 PM

FreeSolvE: Solvent-Mediated Differentiable Pose Refinement and Ultra-Fast Biophysical Inductive Bias for Molecular Generation and Docking #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11276226/latest

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:03 PM

Prediction-Uncertainty-Aware Adaptive Dual-Timescale Multi- Agent Resource Orchestration for Integrated Energy Lakehouses #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10774990/latest

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:02 PM

High-throughput serial two-photon tomography with BakingTray and BrainSaw #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.28.748989v1

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:02 PM

Glymphatic Imaging in Multiple Sclerosis: Microstructural Constraints on DTI-ALPS and Clinical Relevance of gBOLD-CSF Coupling in Relation to Sleep and Disability #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755605v1

@prepub-neurodegen.bsky.socialOct 7, 2026, 4:02 PM

Desktop iDMS: A stand-alone application of intelligent differential mobility spectrometry (iDMS), a neural net-work that predicts optimal separation and compensa-tion voltages for field asymmetric differential ion mob #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.02.756329v1

@plosbiology.orgOct 7, 2026, 2:33 PM

Why do some neurons die in #neurodegeneration while closely related neighbors survive? This Essay by Dong Won Kim argues that disease resistance may depend on maintenance of a neuron's #cell identity and proposes tests of the model.
🧪 #AcademicSky
plos.io/4y7cGbA

Reversible cell-state remodeling vs. identity-maintenance failure in adult neurons. An adult neuron with stable subtype identity (left) depends on continued operation of four interrelated regulatory components, shown in the inset legend: (1) identity transcription factors; (2) accessible identity enhancers; (3) coherent terminal effector gene modules; and (4) active repression of alternative gene programs belonging to other cell types. Under stress (metabolic, proteostatic, inflammatory, or pathological), the neuron can follow one of two trajectories. (A) In reversible cell-state remodeling, the neuron mounts adaptive responses such as the heat-shock response and the unfolded protein response (UPR), while identity transcription factor activity, enhancer accessibility, terminal effector modules, and repression of alternative programs remain intact. When the stress is removed, the neuron returns to its prior identity state. (B) In identity-maintenance failure, similar stress responses occur, but the regulatory machinery that stabilizes subtype identity itself weakens: identity transcription factor activity falls, identity enhancers lose accessibility, terminal effector modules decohere, and repression of alternative or neighboring-cell programs (orange) fails, allowing those programs to be expressed. After sustained disruption of this machinery, return to the prior identity state may be incomplete, delayed, or unstable even after the initiating stress is removed (broken recovery arrow), and degeneration may follow. The stress-response components are shown at comparable intensity in both panels to emphasize that the framework concerns identity-regulatory outcomes under matched stress exposure, not differences in stress response itself. Neuron illustration adapted from NIH BioArt Source, “Healthy neuron” (BIOART-000197), Public Domain, Courtesy of NIAID.
@papers-neurodegen.bsky.socialOct 7, 2026, 1:03 PM

From a prion seed to a tree of discoveries: Byron Caughey’s RT-QuIC legacy in protein misfolding research #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1007/s00401-026-03094-3

@prepub-neurodegen.bsky.socialOct 7, 2026, 1:02 PM

Triple-Omics Analysis Unveiled the Neuroprotective Mechanisms of Akkermansia muciniphila in an Environmental Exposure-Linked Mouse Model of Alzheimer's Disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755812v1

@prepub-neurodegen.bsky.socialOct 7, 2026, 1:02 PM

PFKFB3 inhibition restores β-cell responsiveness to acetylcholine in a 3xTg-AD pancreatic tissue-slice mode #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755766v1

@prepub-neurodegen.bsky.socialOct 7, 2026, 1:02 PM

Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1

@papers-neurodegen.bsky.socialOct 7, 2026, 10:05 AM

Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons #NeuroDegeneration 🧪🧠
https://www.nature.com/articles/s41593-026-02464-0

@papers-neurodegen.bsky.socialOct 7, 2026, 10:05 AM

Serum Chitotriosidase Links to Activated Glia at Chronic Active Lesion Rims in Multiple Sclerosis Brain #NeuroDegeneration 🧪🧠
https://onlinelibrary.wiley.com/doi/10.1002/ana.78386?af=R

@papers-neurodegen.bsky.socialOct 7, 2026, 10:05 AM

Clusterin is enriched in plaque‐associated astrocytes and localizes to synapses in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71885?af=R

@papers-neurodegen.bsky.socialOct 7, 2026, 10:05 AM

Cell‐based polygenic risk scores predict clinical progression and prioritize network‐based therapeutic targets in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71895?af=R

@papers-neurodegen.bsky.socialOct 7, 2026, 10:05 AM

A murine model of amyloid‐enhanced tauopathy: Comparison of wild‐type and P301L‐tau #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71788?af=R

@papers-neurodegen.bsky.socialOct 7, 2026, 10:05 AM

Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71890?af=R