Wang et al. unveil RegVelo, a groundbreaking framework that combines gene regulatory networks with RNA velocity, pinpointing key regulators shaping cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Groundbreaking study reveals a co-culture system of ESCs with extra-embryonic cells, mimicking primitive streak formation—a key to understanding human gastrulation! PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 revolutionizes RNA editing by harnessing endogenous ADAR with engineered arRNAs, paving the way for precise edits via AlphaFold 3 structure insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mendelian randomization reveals causal ties between risk factors & disease progression. Index event bias impacts analyses significantly. #Epidemiology PMID:42372731, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00230-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism using Bacteroides fragilis toxin to thrive in the inflamed gut, fueling oxidative growth and contributing to colitis and colorectal cancer. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements (TEs) make up nearly 50% of mammalian genomes, influencing gene expression and disease through their DNA and RNA forms, despite mostly losing mobility. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

E. coli's DnaB helicase, key in DNA replication, efficiently unwinds DNA when correctly loaded, challenging the old view of limited ATP-motor coupling efficiency. PMID:42373613, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73652-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neonatal MR1T cells show diverse TCRs but only 30% have bacterial recognition compared to adults (70%). Significant insight into sepsis protection. Discuss! PMID:42373629, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74998-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals enzyme clustering enhances CoQ biosynthesis via substrate channeling. Molecular dynamics and biochemical tests show COQ metabolons form at phase transitions. PMID:42373663, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74806-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Disrupting Ip6k2-Runx2 stops osteoblasts and osteoclasts from coupling, offering new osteoporosis treatment. Dual role discovery could change OP management. PMID:42373645, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75098-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

D-SPIN constructs gene regulatory network models from single-cell RNA-seq, revealing how cells modulate gene expression to maintain homeostasis and respond to perturbations. PMID:42127893, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows promising results: Neoadjuvant fulvestrant + abemaciclib achieves high clinical benefit rate in advanced low-grade serous ovarian carcinoma. Insightful findings! PMID:42374029, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74571-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery of GPNMB CAR T cells could transform multi-cancer therapy, optimizing target identification from 1000s of single-cell RNA sequences. Exciting potential! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Key findings reveal that MBS1, a mediator of 1O2 responses, forms protein condensates in chloroplasts, enhancing high-light tolerance and protecting against photodamage. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

3D diffusion autoencoders analyze cardiac MRI data from 71,017 UK Biobank participants, unveiling reproducible, heritable phenotypes (h² = 4–18%). Fascinating insights! PMID:42373625, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74575-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing embryonic research: Primates' organogenetic embryoids from cTBLCs showcase totipotent features, advancing models from zygote to early organogenesis. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years before diagnosis, enhancing prevention strategies beyond IL-1β inhibition's high NNT. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring >20 neuronal autoantibodies in diagnosing autoimmune encephalitis can transform treatment approaches. Discuss! 🔍🧠 PMID:42371614, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.2027 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in human CD4+ T cells found 43 pro- and 91 anti-HIV host factors, unveiling diverse antiviral mechanisms and potential therapeutic targets. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The cGAS-STING pathway detects dsDNA, linking innate immunity to tissue homeostasis and antitumor activity. Its role in inflammation opens new therapeutic avenues. PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪